Growth hormone (GH) is integrally involved in the development of the central nervous system (CNS), as well as during its recovery from injury, two processes that share many similarities and may influence CNS functionality. This review discusses some of the most recent findings in the field and, in particular, the ontogeny, distribution, regulation and putative functions of GH and its receptor within the CNS, particularly during development. The relative roles of peripheral GH, acting in part through insulin-like growth factor-I, and of the autocrine/paracrine GH system within the brain are considered. The potential role of GH as a therapeutic agent to influence brain development and function is discussed.
© 2005 S. Karger AG, Basel
Dr. Arjan Scheepens
Liggins Institute, Faculty of Medicine and Health Sciences, University of Auckland
Private Bag 92019
Auckland (New Zealand)
Tel. +64 9 373 7599, ext. 86689, Fax +64 9 373 7497, E-Mail firstname.lastname@example.org
Published online: January 20, 2006
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 0, Number of References : 84
Hormone Research (From Developmental Endocrinology to Clinical Research)
Vol. 64, No. Suppl. 3, Year 2005 (Cover Date: February 2006)
Journal Editor: Czernichow, P. (Paris)
ISSN: 0301–0163 (print), 1423–0046 (Online)
For additional information: http://www.karger.com/HRE
Article / Publication Details
Published online: 1/27/2006
Issue release date: February 2006
Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 0
ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)
For additional information: http://www.karger.com/HRP
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