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Vol. 72, No. 5, 2005
Issue release date: December 2005
Section title: Original Paper
Pathobiology 2005;72:233–240
(DOI:10.1159/000089417)

Expression of Liver-Type Fatty-Acid-Binding Protein, Fatty Acid Synthase and Vascular Endothelial Growth Factor in Human Lung Carcinoma

Kawamura T. · Kanno R. · Fujii H. · Suzuki T.
Departments of aPathology and bSurgery, Fukushima Medical University School of Medicine, Fukushima, and cDepartment of Signal Transduction, Graduate School of Medical and Dental Sciences, Niigata University, Niigata, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 12/21/2005

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 6

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: http://www.karger.com/PAT

Abstract

Objective: A key enzyme of fatty acid synthesis, fatty acid synthase (FAS), is expressed in human cancers, including squamous-cell carcinoma of the lung, and long-chain fatty acids are intracellularly transported and/or taken up from blood by fatty-acid-binding proteins (FABPs). Since the liver-type (L-) FABP, a member of the FABPs, is detected in a subset of gastric adenocarcinomas, the expression of FAS, L-FABP and vascular endothelial growth factor (VEGF) was investigated in human lung carcinomas to elucidate the mechanisms of production and transportation of fatty acid(s) in cancer. Methods: Expression of L-FABP, FAS and VEGF in 199 surgically resected lung carcinomas was examined immunohistochemically. Possible associations of the expression of each protein with major clinicopathological factors were analyzed. Results: L-FABP was detected in 60% (120 of 199) of the lung carcinoma cases; detection was increased in large-cell carcinoma (80%) and adenosquamous carcinoma (83%), but low in squamous-cell carcinoma (47%) and in small-cell carcinoma (57%). Overall expression of FAS was 67.3% (134 of 199 cases) and that of VEGF was 86.8% (158 of 199 cases), respectively. Expression of L-FABP was not correlated with the FAS status, but there was a tendency to co-expression of L-FABP and VEGF. There was no association between L-FABP, FAS or VEGF expression and clinicopathological data. Conclusions: L-FABP, FAS and VEGF are highly expressed in human lung cancer, and expression of L-FABP is associated with that of VEGF but not that of FAS, suggesting that L-FABP might be involved in the uptake of fatty acid(s) from the bloodstream.


  

Author Contacts

Dr. Toshimitsu Suzuki
Department of Pathology
Fukushima Medical University School of Medicine
1 Hikarigaoka, Fukushima City, 960-1295 (Japan)
Tel. +81 24 548 1169, Fax +81 24 548 7151, E-Mail tmt@fmu.ac.jp

  

Article Information

Received: November 15, 2004
Accepted: May 24, 2005
Number of Print Pages : 8
Number of Figures : 2, Number of Tables : 6, Number of References : 41

  

Publication Details

Pathobiology

Vol. 72, No. 5, Year 2005 (Cover Date: Released December 2005)

Journal Editor: Borisch, B. (Geneva)
ISSN: 1015–2008 (print), 1423–0291 (Online)

For additional information: http://www.karger.com/PAT


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 12/21/2005

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 6

ISSN: 1015-2008 (Print)
eISSN: 1423-0291 (Online)

For additional information: http://www.karger.com/PAT


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