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Vol. 115, No. 1-2, 2006
Issue release date: January 2006
Section title: Original Paper
Acta Haematol 2006;115:53–57
(DOI:10.1159/000089466)

Side Effects of Oral Iron Prophylaxis in Pregnancy – Myth or Reality?

Milman N. · Byg K.-E. · Bergholt T. · Eriksen L.
aDepartment of Obstetrics, Gentofte Hospital, and bDepartment of Medicine B, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/9/2005
Accepted: 5/19/2005
Published online: 1/18/2006

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 3

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

Background: It is a common belief among women that iron compounds have unpleasant gastrointestinal side effects. Objective: To assess the gastrointestinal side effects of iron prophylaxis in pregnancy. Methods: A randomized, double-blind study comprising 404 healthy pregnant women allocated to four groups taking ferrous iron supplement (as fumarate) in doses of 20 (n = 99), 40 (n = 100), 60 (n = 102) and 80 mg (n = 103) daily from 18 weeks of gestation to delivery. Iron supplement was predominantly taken at bedtime. Gastrointestinal symptoms (nausea, vomiting, epigastric pain, eructation, pyrosis, meteorism, borborygmi, colic pain, flatulence, constipation, thin feces, diarrhea), black feces, and use of laxatives were recorded by interview at 18, 32 and 39 weeks of gestation. Results: The frequencies of gastrointestinal symptoms were not significantly different in the four iron supplement groups either at inclusion or at 32 and 39 weeks of gestation and thus not related to the iron dose. Conclusion: This study shows that a supplement of 20–80 mg ferrous iron (as fumarate), taken between meals, has no clinically significant gastrointestinal side effects. The implementation of iron prophylaxis to pregnant women should not be compromised by undue concern of non-existing side effects.


  

Author Contacts

Nils Milman, MD
Department of Medicine B 2142
Rigshospitalet
DK–2100 Copenhagen Ø (Denmark)
Tel. +45 35 45 26 01, Fax +45 35 45 26 48, E-Mail milman@h.dk

  

Article Information

Received: May 9, 2005
Accepted after revision: May 19, 2005
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 3, Number of References : 12

  

Publication Details

Acta Haematologica

Vol. 115, No. 1-2, Year 2006 (Cover Date: January 2006)

Journal Editor: Ben-Bassat, I. (Tel Hashomer)
ISSN: 0001–5792 (print), 1421–9662 (Online)

For additional information: http://www.karger.com/AHA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/9/2005
Accepted: 5/19/2005
Published online: 1/18/2006

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 3

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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