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Vol. 21, No. 1, 2006
Issue release date: December 2005
Section title: Original Research Article
Dement Geriatr Cogn Disord 2006;21:51–58
(DOI:10.1159/000089515)

Conversion of Mild Cognitive Impairment to Dementia: Predictive Role of Mild Cognitive Impairment Subtypes and Vascular Risk Factors

Ravaglia G. · Forti P. · Maioli F. · Martelli M. · Servadei L. · Brunetti N. · Pantieri G. · Mariani E.
aDepartment of Internal Medicine, Cardioangiology and Hepatology, University Hospital S. Orsola-Malpighi, bLaboratory of Immunology and Genetics, Codivilla Putti Research Institute, Rizzoli Orthopedic Institute, Bologna, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 7/18/2005
Published online: 12/15/2005

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 5

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Mild cognitive impairment (MCI) is regarded as a precursor to dementia, but not all patients with MCI develop dementia. We followed up 165 elderly outpatients with MCI for a mean of 3 years. The aims were (1) to investigate the risk of conversion to dementia for different MCI subtypes diagnosed according to standardized criteria (amnestic; impairment of memory plus other cognitive domains; nonamnestic); (2) to assess whether the risk of conversion was affected by several established and emerging vascular risk factors. Forty-eight subjects (29%) converted to dementia, and the risk of conversion was doubled for amnestic MCI with respect to the other subtypes. Independently of MCI subtype, risk of conversion was associated with atrial fibrillation and low serum folate levels. Our results show that current diagnostic criteria for MCI define heterogeneous populations, but some potentially treatable vascular risk factors may be of help in predicting conversion to dementia.


  

Author Contacts

Prof. Giovanni Ravaglia
Department of Internal Medicine, Cardioangiology and Hepatology
University Hospital S. Orsola-Malpighi, Via Massarenti 9
IT–40138 Bologna (Italy)
Tel. +39 051 6364310, Fax +39 051 340877, E-Mail ravaglia@med.unibo.it

  

Article Information

Accepted: July 18, 2005
Published online: November 4, 2005
Number of Print Pages : 8
Number of Figures : 1, Number of Tables : 5, Number of References : 39

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 21, No. 1, Year 2006 (Cover Date: December 2005)

Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)

For additional information: http://www.karger.com/DEM


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 7/18/2005
Published online: 12/15/2005

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 5

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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