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Vol. 21, No. 2, 2006
Issue release date: January 2006
Section title: Original Research Article
Dement Geriatr Cogn Disord 2006;21:59–64
(DOI:10.1159/000089546)

Early-Onset Dementia: Frequency and Causes Compared to Late-Onset Dementia

McMurtray A. · Clark D.G. · Christine D. · Mendez M.F.
V.A. Greater Los Angeles Healthcare System and Department of Neurology, David Geffen School of Medicine at the University of California at Los Angeles, Los Angeles, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 7/18/2005
Published online: 1/20/2006

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Background: Research on the epidemiology of dementia has focused on the elderly. Few investigations have studied differences in etiologic frequencies between early-onset dementia (EOD), with onset at an age of less than 65 years old, and the more common late-onset disorder. Objectives: To determine relative frequencies and characteristics of EOD versus late-onset dementia (LOD; age of onset ≧65 years) diagnosed in a large memory disorders program over a 4-year period. Methods: We reviewed medical records, including an extensive neurobehavioral and neurological evaluation, of all patients seen at a large Veteran’s Affairs Medical Center Memory Disorders clinic between 2001 and 2004 and assessed demographic variables, final diagnoses, presence of dementia, and differential diagnosis of dementing illnesses. Results: Among 1,683 patients presenting for evaluation of an acquired decline in memory or cognition, 948 (56%) met established clinical criteria for a dementing illness. About 30% (n = 278) of these had an age of onset of <65 years, compared to 670 with LOD. Patients were predominantly male (98%). Compared to the late-onset group, the EOD patients were less severely impaired on presentation, but they did not differ in gender distribution or educational background. The EOD group had significantly more dementia attributed to traumatic brain injury, alcohol, human immunodeficiency virus (HIV), and frontotemporal lobar degeneration compared to the LOD patients. In contrast, the LOD group had significantly more Alzheimer’s disease compared to the EOD group. Conclusions: This study, conducted at a Veterans Affairs Hospital, is the largest series to date on EOD, and found a previously unexpectedly large number of patients below the age of 65 with cognitive deficits and impaired functioning consequent to head trauma, alcohol abuse, and HIV. These findings highlight the differential distribution and importance of preventable causes of dementia in the young.


  

Author Contacts

A.M. McMurtray
Neurobehavior Unit (116AF), V.A. Greater Los Angeles Healthcare System
11301 Wilshire Blvd., Los Angeles, CA 90073 (USA)
Tel. +1 310 478 3711, ext. 44208, Fax +1 310 268 4181
E-Mail amcmurtray@mednet.ucla.edu

  

Article Information

Accepted: July 18, 2005
Published online: November 4, 2005
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 3, Number of References : 27

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 21, No. 2, Year 2006 (Cover Date: January 2006)

Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)

For additional information: http://www.karger.com/DEM


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 7/18/2005
Published online: 1/20/2006

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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