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Vol. 21, No. 1-2, 2006
Issue release date: January 2006
Section title: Original Paper
Cerebrovasc Dis 2006;21:18–25
(DOI:10.1159/000089589)

Risk Factors for Primary Intracerebral Hemorrhage

A Population-Based Nested Case-Control Study

Zia E.a, b · Pessah-Rasmussen H.a · Khan F.A.b · Norrving B.c · Janzon L.b · Berglund G.b · Engström G.b
Departments of aNeurology and bClinical Science, Malmö University Hospital, Malmö, and cDepartment of Neurology, Lund University Hospital, Lund, Sweden

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/11/2005
Accepted: 7/5/2005
Published online: 1/13/2006
Issue release date: January 2006

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 5

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Purpose: In this population-based study, risk factors for primary intracerebral hemorrhage (PICH) and PICH subtypes were explored in a nested case-control design. Method: Risk factors were determined in 22,444 men and 10,902 women (mean age 47 years) who participated in a health-screening programme between 1974 and 1991. 147 subjects with CT or autopsy-verified first-ever PICH during the follow-up period (mean 14 years) were compared with 1,029 stroke-free controls, matched for age, sex and screening-year. Results: As compared to controls, PICH cases had significantly higher blood pres- sure (135/91 vs. 127/85 mm Hg), triglycerides (1.7 vs. 1.4 mmol/l), BMI (25.5 vs. 24.8) and shorter stature (1.73 vs. 1.74 m). Diabetes (6.9 vs. 2.8 %) and history of psychiatric morbidity (19.7 vs. 11.0 %) were more common in PICH cases and more of them were living alone (35.4 vs. 25.5%). After adjustment in a backward logistic regression model, high systolic blood pressure, diabetes, high triglycerides, short stature and psychiatric morbidity remained significantly associated with PICH. As compared to the control group, high systolic blood pressure was significantly associated both with nonlobar and lobar PICH. Diabetes and psychiatric morbidity were associated with nonlobar PICH. Smoking doubled the risk for lobar PICH, but was unrelated to nonlobar PICH. Conclusion: In this prospective population-based study, hypertension, diabetes, height, triglycerides and psychiatric morbidity were risk factors for PICH. Smoking was a risk factor for lobar PICH only.

© 2006 S. Karger AG, Basel


  

Author Contacts

Dr. E. Zia
Department of Neurology
Malmö University Hospital
SE–20502 Malmö (Sweden)
Tel./Fax +46 40331000/336228, E-Mail elisabet.zia@skane.se

  

Article Information

Received: March 11, 2005
Accepted: July 5, 2005
Published online: November 8, 2005
Number of Print Pages : 8
Number of Figures : 0, Number of Tables : 5, Number of References : 44

  

Publication Details

Cerebrovascular Diseases

Vol. 21, No. 1-2, Year 2006 (Cover Date: January 2006)

Journal Editor: Bogousslavsky, J. (Lausanne)
ISSN: 1015–9770 (print), 1421–9786 (Online)

For additional information: http://www.karger.com/CED


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/11/2005
Accepted: 7/5/2005
Published online: 1/13/2006
Issue release date: January 2006

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 5

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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