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Vol. 102, No. 3-4, 2006
Issue release date: February 2006
Section title: Original Paper
Nephron Clin Pract 2006;102:c128–c132
(DOI:10.1159/000089671)

Clopidogrel Diminishes Hemodialysis Access Graft Thrombosis

Trimarchi H. · Young P. · Forrester M. · Schropp J. · Pereyra H. · Freixas E.
Department of Medicine,aNephrology Section, and bInternal Medicine Section, Hospital Británico, Buenos Aires, Argentina

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/11/2005
Accepted: 7/21/2005
Published online: 11/11/2005

Number of Print Pages: 1
Number of Figures: 0
Number of Tables: 2

ISSN: (Print)
eISSN: 1660-2110 (Online)

For additional information: http://www.karger.com/NEC

Abstract

Background: The most common complication of hemodialysis (HD) access graft is thrombosis. Clopidogrel, an inhibitor of platelet aggregation, was assessed to prevent this serious complication. Methods: A prospective study in which 24 patients on chronic HD whose vascular accesses were grafts were divided into two groups: group A (n = 12, 50%) consisted of patients who did not receive antithrombotic therapy after graft creation, and group B (n = 12, 50%) received clopidogrel 75 mg/day from 2 days after surgery onwards. Both groups were not different according to age, gender, cause of renal failure, hematocrit levels, platelet counts and Kt/V. All patients’ thrombotic episodes were followed up from the day of graft surgery until thrombosis was diagnosed. Finally, the patient survival difference between both groups was determined. Results: Eleven thrombotic episodes were diagnosed in group A while one event was reported in group B (p < 0.001). Graft access days of patency were significantly longer in group B compared to group A (380.8 ± 170 vs. 90.1 ± 57.2, p < 0.001). Time that elapsed from dialysis initiation to graft creation was not different (group A 18 ± 12 days, group B 20 ± 10 days). Days on HD were different between both groups (group A 208.9 ± 97.2 vs. group B 583.2 ± 287.0, p < 0.001) and all patients from group A (n = 12, 100%) and 2 patients from group B (16.7%) died (p = 0.001). Major bleeding events were not reported. Conclusions: Clopidogrel significantly decreased thrombotic graft episodes. Patients on clopidogrel had a prolonged vascular access patency, longer time on HD and better survival.


  

Author Contacts

Dr. Hernán Trimarchi
Hospital Británico, Perdriel 74
AR–1280 Buenos Aires (Argentina)
Tel. +54 11 4309 6400, Fax +54 11 4304 3393
E-Mail htrimarchi@hotmail.com

  

Article Information

Received: March 11, 2005
Accepted: July 21, 2005
Published online: November 10, 2005
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 2, Number of References : 19

  

Publication Details

Nephron Clinical Practice

Vol. 102, No. 3-4, Year 2006 (Cover Date: February 2006)

Journal Editor: Powis, S.H. (London)
ISSN: 1660–2110 (print), 1660–2110 (Online)

For additional information: http://www.karger.com/NEC


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 3/11/2005
Accepted: 7/21/2005
Published online: 11/11/2005

Number of Print Pages: 1
Number of Figures: 0
Number of Tables: 2

ISSN: (Print)
eISSN: 1660-2110 (Online)

For additional information: http://www.karger.com/NEC


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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