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Table of Contents
Vol. 73, No. 1, 2006
Issue release date: February 2006
Section title: Review
Respiration 2006;73:124–130
(DOI:10.1159/000089814)

Deleterious Effects of Sleep-Disordered Breathing on the Heart and Vascular System

Dincer H.E.a · O’Neill W.b, c
aPulmonary, Critical Care and Sleep Medicine, VA Southern Nevada Health Care System, Las Vegas, Nev., bPulmonary, Critical Care and Sleep Medicine, Medical College of Wisconsin, and cVA Medical Center, Milwaukee, Wisc., USA

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 2/10/2006
Issue release date: February 2006

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES

Abstract

Obstructive sleep apnea (OSA) is the most common form of sleep-disordered breathing, affecting 5–15% of the population. It is characterized by intermittent episodes of partial or complete obstruction of the upper airway during sleep that disrupts normal ventilation and sleep architecture, and is typically associated with excessive daytime sleepiness, snoring, and witnessed apneas. Patients with obstructive sleep apnea present risk to the general public safety by causing 8-fold increase in vehicle accidents, and they may themselves also suffer from the physiologic consequences of OSA; these include hypertension, coronary artery disease, stroke, congestive heart failure, pulmonary hypertension, and cardiac arrhythmias. Of these possible cardiovascular consequences, the association between OSA and hypertension has been found to be the most convincing. Although the exact mechanism has not been understood, there is some evidence that OSA is associated with frequent apneas causing mechanical effects on intrathoracic pressure, cardiac function, and intermittent hypoxemia, which may in turn cause endothelial dysfunction and increase in sympathetic drive. Therapy with continuous positive airway pressure has been demonstrated to improve cardiopulmonary hemodynamics in patients with OSA and may reverse the endothelial cell dysfunction. Despite the availability of diagnostic measures and effective treatment, many patients with sleep-disordered breathing remain undiagnosed. Therefore, OSA continues to be a significant health risk both for affected individuals and for thegeneral public. Awareness and timely initiation of an effective treatment may prevent potential deleterious cardiovascular effects of OSA.

© 2006 S. Karger AG, Basel


  

Author Contacts

H. Erhan Dincer, MD, FCCP
VA Southern Nevada Health Care System, PO Box 360001
North Las Vegas, NV 89036 (USA)
Tel. +1 702 636 6355, Fax +1 702 636 4008
E-Mail Huseyin.Dincer@med.va.gov or erhan_dincer@yahoo.com

  

Article Information

H. Erhan Dincer, MD, FCCP, VA Southern Nevada Health Care System, PO Box 360001, North Las Vegas, NV 89036 (USA) or H. Erhan Dincer, MD, FCCP, 630 S Rancho Road, Las Vegas, NV 89106 (USA), (only for courier mails), Tel. +1 702 6366355, Fax +1 702 6364008, E-Mail: Huseyin.Dincer@med.va.gov or erhan_dincer@yahoo.com

Received: April 25, 2005
Accepted after revision: August 23, 2005
Published online: November 15, 2005
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 0, Number of References : 88

  

Publication Details

Respiration (International Journal of Thoracic Medicine)

Vol. 73, No. 1, Year 2006 (Cover Date: February 2006)

Journal Editor: Bolliger, C.T. (Cape Town)
ISSN: 0025–7931 (print), 1423–0356 (Online)

For additional information: http://www.karger.com/RES


Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 2/10/2006
Issue release date: February 2006

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES


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