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Original Article

Assignment of the NAD-dependent deacetylase sirtuin 5 gene (SIRT5) to human chromosome band 6p23 by in situ hybridization

Mahlknecht U.a · Ho A.D.a · Letzel S.b · Voelter-Mahlknecht S.b

Author affiliations

aUniversity of Heidelberg Medical Center, Department of Hematology/Oncology, Heidelberg (Germany)

Related Articles for ""

Cytogenet Genome Res 112:208–212 (2006)

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Article / Publication Details

First-Page Preview
Abstract of Original Article

Published online: February 10, 2006
Issue release date: February 2006

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR

Abstract

Sirtuin 5 (SIRT5) is a nicotinamide adenine dinucleotide (NAD+)-dependent deacetylase and belongs to the Silent information regulator 2 (Sir2) family of sirtuin histone deacetylases (HDACs), which play a central role in epigenetic gene silencing, DNA repair and recombination, cell-cycle, microtubule organization, and in the regulation of aging. We have isolated and characterized the human SIRT5 genomic sequence, which spans a region of 28,182 bp and which has one single genomic locus. Human SIRT5 consists of eight exons and is found in two isoforms, which encode a 310 aa and a 299 aa protein, respectively. Human SIRT5 is most predominantly expressed in heart muscle cells and in lymphoblasts. Fluorescence in situ hybridization analysis localized the human SIRT5 gene to chromosome 6p23.

© 2006 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Article

Published online: February 10, 2006
Issue release date: February 2006

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: http://www.karger.com/CGR


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