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Vol. 73, No. 2, 2006
Issue release date: March 2006
Section title: Basic Science Investigations
Respiration 2006;73:227–235
(DOI:10.1159/000089923)

Human Airway Smooth Muscle Cells Express Eotaxin in Response to Signaling following Mast Cell Contact

Liu L. · Yang J. · Huang Y.
Department of Respiratory Disease, Renmin Hospital, Wuhan University, Wuhan, China

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Article / Publication Details

First-Page Preview
Abstract of Basic Science Investigations

Published online: 3/22/2006
Issue release date: March 2006

Number of Print Pages: 9
Number of Figures: 6
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES

Abstract

Background: Asthma is a chronic inflammatory disease of the airways. Mast-cell (MC)-derived cytokines may mediate both airway inflammation and remodeling. It has also been shown that airway smooth muscle cells (ASMC) can be a source of proinflammatory cytokines. In the human airways, MC-ASMC cell interactions may have pivotal effects on modulating inflammation. Objectives: We wanted to know whether the production of eotaxin, an important proinflammatory cytokine, through a cell-to-cell contact mechanism of human ASMC activation by MC was mediated by p38 MAPK. Methods: We cocultured normal humanASMC with a human MC line (HMC-1) and assayed for the production of eotaxin. Results: When cultured together, human ASMC and HMC-1 contact induced eotaxin secretion. Separation of HMC-1 and human ASMC by a porous membrane inhibited this induction. Coculturing of human ASMC with HMC-1 induced increased expression of eotaxin gene mRNA. HMC-1-derived cellular membranes caused an increase in eotaxin production in human ASMC. Activation of p38 MAPK was also seen in cocultures by Western blot, whereas eotaxin production in cocultures was significantly inhibited by the p38 inhibitor SB203580. Conclusion: These novel studies reveal the importance of cell-to-cell interactions in the complex milieu of airway inflammation.

© 2006 S. Karger AG, Basel


  

Author Contacts

L. Liu
Department of Respiratory Disease
Renmin Hospital, Wuhan University
Wuhan 430060 (China)
Tel. +86 27 6227 6350, E-Mail cutliu@sohu.com

  

Article Information

Received: May 26, 2005
Accepted after revision: August 23, 2005
Published online: November 22, 2005
Number of Print Pages : 9
Number of Figures : 6, Number of Tables : 0, Number of References : 30

  

Publication Details

Respiration (International Journal of Thoracic Medicine)

Vol. 73, No. 2, Year 2006 (Cover Date: March 2006)

Journal Editor: Bolliger, C.T. (Cape Town)
ISSN: 0025–7931 (print), 1423–0356 (Online)

For additional information: http://www.karger.com/RES


Article / Publication Details

First-Page Preview
Abstract of Basic Science Investigations

Published online: 3/22/2006
Issue release date: March 2006

Number of Print Pages: 9
Number of Figures: 6
Number of Tables: 0

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES


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