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Vol. 181, No. 1, 2005
Issue release date: 2005
Section title: Review
Cells Tissues Organs 2005;181:1–10
(DOI:10.1159/000089964)

Understanding Muscle Architectural Adaptation: Macro- and Micro-Level Research

Blazevich A.J. · Sharp N.C.C.
Centre for Sports Medicine and Human Performance, Brunel University, Uxbridge, UK

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Article / Publication Details

First-Page Preview
Abstract of Review

Received: 9/12/2005
Published online: 1/27/2006
Issue release date: 2005

Number of Print Pages: 10
Number of Figures: 5
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO

Abstract

Recent research using muscle-imaging techniques has revealed a remarkable plasticity of human muscle architecture where significant changes in fascicle lengths and angles have resulted from the chronic performance, or cessation, of strong muscle contractions. However, there is a paucity of data describing architectural adaptations to chronic stretching, disuse and immobilization, illness, and aging, and those data that are available are equivocal. Understanding their impact is important in order that effective interventions for illness/injury management and rehabilitation, and programs to improve the physical capacity of workers, the aged and athletes can be determined. Nonetheless, recent advances in myocellular research could provide a framework allowing the prediction of architectural changes in these understudied areas. Examination of the site-specific response to mechanical stress of calpain-dependent ubiquitin-proteasome proteolysis, or of the cellular response to stress after the knockout (or incapacitation) of sarcomeric and cytoskeletal proteins involved in cellular signal transduction, provides an exciting paradigm by which myocellular adaptation can be described. Such research might contribute to the understanding of macro-level changes in muscle architecture.

© 2005 S. Karger AG, Basel


  

Author Contacts

Anthony J. Blazevich, PhD
Centre for Sports Medicine and Human Performance
Brunel University
Uxbridge, UB8 3PH (UK)
Tel. +44 1895 266 465, Fax +44 1895 269 769, E-Mail anthony.blazevich@brunel.ac.uk

  

Article Information

Accepted after revision: September 12, 2005
Number of Print Pages : 10
Number of Figures : 5, Number of Tables : 0, Number of References : 117

  

Publication Details

Cells Tissues Organs (in vivo, in vitro)

Vol. 181, No. 1, Year 2005 (Cover Date: 2005)

Journal Editor: Denker, H.-W. (Essen)
ISSN: 1422–6405 (print), 1422–6421 (Online)

For additional information: http://www.karger.com/CTO


Article / Publication Details

First-Page Preview
Abstract of Review

Received: 9/12/2005
Published online: 1/27/2006
Issue release date: 2005

Number of Print Pages: 10
Number of Figures: 5
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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