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Vol. 23, No. 3-4, 2005
Issue release date: February 2006
Section title: Paper
Dig Dis 2005;23:232–240
(DOI:10.1159/000090170)

Molecular Mechanisms of Alcoholic Pancreatitis

Apte M.V. · Pirola R.C. · Wilson J.S.
Pancreatic Research Group, University of New South Wales, Sydney, Australia

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 2/27/2006

Number of Print Pages: 9
Number of Figures: 1
Number of Tables: 0

ISSN: 0257-2753 (Print)
eISSN: 1421-9875 (Online)

For additional information: http://www.karger.com/DDI

Abstract

Alcoholic pancreatitis is a major complication of alcohol abuse. Since only a minority of alcoholics develop pancreatitis, there has been a keen interest in identifying the factors that may confer individual susceptibility to the disease. Numerous possibilities have been evaluated including diet, drinking patterns and a range of inherited factors. However, at the present time, no susceptibility factor has been unequivocally identified. In contrast, considerable progress has been made with respect to the constant effects of alcohol on the pancreas. The molecular mechanisms of alcohol-induced pancreatic injury are being increasingly defined with an emphasis, in recent years, on the acinar cell itself as the principal site on ethanol-related damage. It has now been established that the acinar cell is capable of metabolizing alcohol and that the direct toxic effects of alcohol and/or its metabolites on acinar cells may predispose the gland to autodigestive injury in the presence of an appropriate triggering factor. A significant recent development relates to the characterization of pancreatic stellate cells, increasingly implicated in alcoholic pancreatic fibrosis. Here the current concepts regarding the mechanisms/pathways mediating alcohol-induced pancreatic injury are outlined.


  

Author Contacts

Assoc. Prof. M.V. Apte
Pancreatic Research Group, South Western Sydney Clinical School
University of New South Wales, Level 2, Thomas and Rachel Moore
Education Centre, Liverpool Hospital, Liverpool, NSW 2170 (Australia)
Tel. +61 2 9828 4931, Fax +61 2 9828 4970, E-Mail m.apte@unsw.edu.au

  

Article Information

Number of Print Pages : 9
Number of Figures : 1, Number of Tables : 0, Number of References : 88

  

Publication Details

Digestive Diseases (State-of-the-Art Clinical Reviews)

Vol. 23, No. 3-4, Year 2005 (Cover Date: February 2006)

Journal Editor: Malfertheiner, P. (Magdeburg)
ISSN: 0257–2753 (print), 1421–9875 (Online)

For additional information: http://www.karger.com/DDI


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 2/27/2006

Number of Print Pages: 9
Number of Figures: 1
Number of Tables: 0

ISSN: 0257-2753 (Print)
eISSN: 1421-9875 (Online)

For additional information: http://www.karger.com/DDI


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