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Vol. 26, No. 2, 2006
Issue release date: February 2006
Section title: Original Paper
Neuroepidemiology 2006;26:61–67
(DOI:10.1159/000090250)

Odor Identification and Decline in Different Cognitive Domains in Old Age

Wilson R.S. · Arnold S.E. · Tang Y. · Bennett D.A.
aRush Alzheimer’s Disease Center, bRush Institute for Healthy Aging, Departments of cNeurological Sciences, dBehavioral Sciences, eInternal Medicine, Rush University Medical Center, Chicago, Ill., and the fCenter for Neurobiology and Behavior, University of Pennsylvania, Philadelphia, Pa., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/8/2005
Published online: 2/10/2006

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 2

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED

Abstract

The authors examined the association of odor identification with rate of decline in different cognitive systems. Participants are 481 older persons from the Rush Memory and Aging Project. At baseline, the Brief Smell Identification Test was administered. At annual intervals for up to 3 years, a battery of 19 cognitive tests was administered from which previously established composite measures of 5 cognitive domains were derived. In mixed-effects models adjusted for age, sex, and education, lower odor identification score was associated with lower function at baseline in each cognitive domain. Lower score was also associated with more rapid decline in perceptual speed (estimate = 0.015, SE = 0.006, p = 0.013) and episodic memory (estimate = 0.012, SE = 0.006, p = 0.030) but not with rate of decline in semantic memory, working memory, or visuospatial ability. Thus, on average, a person with a low odor identification score (6, 10th percentile) declined more than twice as rapidly in perceptual speed and episodic memory as a person with a high score (11, 90th percentile). Results were unchanged in subsequent analyses that controlled for cigarette smoking or clinically diagnosed stroke. The results indicate that impaired odor identification in old age is associated with impaired global cognition and more rapid decline in perceptual processing speed and episodic memory.


  

Author Contacts

Robert S. Wilson, PhD
Rush Alzheimer’s Disease Center, Rush University Medical Center
600 S. Paulina, Suite 1038
Chicago, IL 60612 (USA)
Tel. +1 312 942 2354, Fax +1 312 942 2297, E-Mail rwilson@rush.edu

  

Article Information

Published online: December 13, 2005
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 2, Number of References : 55

  

Publication Details

Neuroepidemiology

Vol. 26, No. 2, Year 2006 (Cover Date: February 2006)

Journal Editor: Román, G.C. (San Antonio, Tex.)
ISSN: 0251–5350 (print), 1423–0208 (Online)

For additional information: http://www.karger.com/NED


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 8/8/2005
Published online: 2/10/2006

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 2

ISSN: 0251-5350 (Print)
eISSN: 1423-0208 (Online)

For additional information: http://www.karger.com/NED


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