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Vol. 24, No. 1-2, 2006
Issue release date: May 2006
Section title: Review Article
Dig Dis 2006;24:59–69
(DOI:10.1159/000090309)

Drugs Acting on Serotonin Receptors for the Treatment of Functional GI Disorders

Tonini M.a · Pace F.b
aDepartment of Physiological and Pharmacological Sciences, University of Pavia, Pavia, and bDivision of Gastroenterology, ‘L. Sacco’ University Hospital, Milan, Italy

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Article / Publication Details

First-Page Preview
Abstract of Review Article

Published online: 5/12/2006
Issue release date: May 2006

Number of Print Pages: 11
Number of Figures: 2
Number of Tables: 2

ISSN: 0257-2753 (Print)
eISSN: 1421-9875 (Online)

For additional information: http://www.karger.com/DDI

Abstract

In the gut, serotonin (5-hydroxytryptamine: 5-HT) exerts a variety of effects on intrinsic enteric neurons, extrinsic afferents, enterocytes and smooth muscle cells, which are related to the expression of multiple 5-HT receptor types and subtypes regulating motility, vascular tone, secretion and perception. Agonists and antagonists at 5-HT receptors have gained access to the market for the two major variants of the irritable bowel syndrome (IBS), a functional disorder characterized by abdominal pain associated with diarrhea and/or constipation in the absence of any organic abnormality. Indeed, the 5-HT3 receptor antagonist alosetron is available in the US market for the treatment of women with severe, diarrhea-predominant IBS (D-IBS) refractory to conventional therapy, whereas tegaserod, a partial 5-HT4 receptor agonist, has been approved by the FDA and other regulatory agencies for the treatment of women with constipation-predominant IBS (C-IBS) or functional constipation. This review is mainly intended to discuss the role of non-neuronal (paracrine) and neuronal 5-HT in the pathophysiology of functional gastrointestinal disorders (FGIDs), such as IBS and functional dyspepsia, and the mechanisms through which drugs acting on 5-HT receptors regulate visceral motility, perception and secretion in these two conditions.

© 2006 S. Karger AG, Basel


  

Author Contacts

Prof. Marcello Tonini
Department of Physiological and Pharmacological Sciences, University of Pavia
Piazza Botta, 11
IT–27100 Pavia (Italy)
Tel. +39 0382 986 381/4, Fax +39 0382 986 385, E-Mail tonini@unipv.it

  

Article Information

Number of Print Pages : 11
Number of Figures : 2, Number of Tables : 2, Number of References : 86

  

Publication Details

Digestive Diseases (Clinical Reviews)

Vol. 24, No. 1-2, Year 2006 (Cover Date: May 2006)

Journal Editor: Malfertheiner, P. (Magdeburg)
ISSN: 0257–2753 (print), 1421–9875 (Online)

For additional information: http://www.karger.com/DDI


Article / Publication Details

First-Page Preview
Abstract of Review Article

Published online: 5/12/2006
Issue release date: May 2006

Number of Print Pages: 11
Number of Figures: 2
Number of Tables: 2

ISSN: 0257-2753 (Print)
eISSN: 1421-9875 (Online)

For additional information: http://www.karger.com/DDI


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.