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Table of Contents
Vol. 12, No. 2, 2006
Issue release date: March 2006
Section title: Research Report
Eur Addict Res 2006;12:91–95
(DOI:10.1159/000090428)

Feasibility and Acceptability of an Intranasal Diamorphine Spray as an Alternative to Injectable Diamorphine for Maintenance Treatment

Mitchell T.B. · Lintzeris N. · Bond A. · Strang J.
National Addiction Centre, Institute of Psychiatry, King’s College, and South London and Maudsley NHS Trust, London, UK

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Article / Publication Details

First-Page Preview
Abstract of Research Report

Published online: March 17, 2006
Issue release date: March 2006

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1022-6877 (Print)
eISSN: 1421-9891 (Online)

For additional information: http://www.karger.com/EAR

Abstract

An intranasal (IN) diamorphine spray was investigated as a possible alternative to injectable diamorphine for maintenance treatment. Plasma morphine and 6-monoacetylmorphine (6MAM) concentrations and pharmacodynamic responses were measured for 4 h following intravenous (IV) and IN administration of 40 mg diamorphine in 4 patients prescribed injectable diamorphine. The two routes were primarily differentiated by the significantly greater speed and magnitude of peak plasma morphine and 6MAM concentrations for IV versus IN diamorphine. Beyond this initial peak, mean ratings suggested that withdrawal suppression and positive effects were at least as strong for IN compared to IV administration. All subjects gave favourable appraisals of the IN diamorphine spray, citing advantages including ease of use, the avoidance of needle hazards, and reduced stigma. IN administration may be an alternative or supplementary form of diamorphine maintenance and deserves serious further investigation.

© 2006 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Research Report

Published online: March 17, 2006
Issue release date: March 2006

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 1

ISSN: 1022-6877 (Print)
eISSN: 1421-9891 (Online)

For additional information: http://www.karger.com/EAR


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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