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Table of Contents
Vol. 68, No. 1, 2006
Issue release date: March 2006
Section title: Paper
ORL 2006;68:48–55
(DOI:10.1159/000090491)

Primary and Secondary Auditory Cortex Stimulation for Intractable Tinnitus

De Ridder D.a · De Mulder G.a · Verstraeten E.b · van der Kelen K.a · Sunaert S.c · Smits M.c · Kovacs S.c · Verlooy J.a · Van de Heyning P.a · Moller A.R.d
aDepartment of Neurosurgery and Otorhinolaryngology, University Hospital Antwerp, Antwerp, bDepartment of Psychology, Free University Brussels, Brussels, and cDepartment of Radiology, University Hospital Louvain, Louvain, Belgium; dSchool of Behavioral and Brain Sciences, University of Texas at Dallas, Dallas, Tex., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Received: May 09, 2005
Accepted: July 29, 2005
Published online: March 07, 2006
Issue release date: March 2006

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 2

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL

Abstract

Introduction: Recent research suggests tinnitus is a phantom phenomenon based on hyperactivity of the auditory system, which can be visualized by functional neuroimaging, and transiently modulated by transcranial magnetic stimulation (TMS). We present the results of the first implanted electrodes on the primary and secondary auditory cortex after a successful TMS suppression. Methods and Materials: Twelve patients underwent an auditory cortex implantation, 10 for unilateral and 2 for bilateral tinnitus, based on >50% suppression applying TMS. Results were analyzed for pure tone tinnitus and white noise tinnitus. Results: TMS results in 77% pure tone tinnitus and 67% white noise reduction. Electrical stimulation via an implanted electrode results in a mean of 97% pure tone tinnitus and 24% white noise suppression. Mean Visual Analogue Scale score decreases from 9.5 to 1.5 for pure tone and from 8.8 to 6.8 for white noise postoperatively. Discussion: Pure tone tinnitus might be the conscious percept of focal neuronal hyperactivity of the auditory cortex. Once visualized, this hyperactivity can be modulated by neurostimulation. Conclusion: The preliminary results of the first implantations suggest that patients with unilateral pure tone tinnitus are good surgical candidates for electrode implantation and permanent electrical stimulation of the auditory cortex, provided that the tinnitus is of recent origin and can be suppressed by TMS.

© 2006 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Received: May 09, 2005
Accepted: July 29, 2005
Published online: March 07, 2006
Issue release date: March 2006

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 2

ISSN: 0301-1569 (Print)
eISSN: 1423-0275 (Online)

For additional information: http://www.karger.com/ORL


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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