Journal Mobile Options
Table of Contents
Vol. 50, No. 2, 2006
Issue release date: February 2006
Section title: Original Paper
Ann Nutr Metab 2006;50:95–102
(DOI:10.1159/000090496)

Erythrocyte Membrane Phospholipid Composition as a Biomarker of Dietary Fat

Fuhrman B.J. · Barba M. · Krogh V. · Micheli A. · Pala V. · Lauria R. · Chajes V. · Riboli E. · Sieri S. · Berrino F. · Muti P.
aDepartment of Social and Preventive Medicine, University at Buffalo, State University of New York, Buffalo, N.Y., USA; bDepartment of Endocrinology and Medical Oncology, Federico II Medical School of Naples, Naples, cUnita’ Operativa di Epidemiologia, and dUnità di Epidemiologia Descrittiva e Programmazione Sanitaria, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy; eLaboratoire de Biologie des Tumeurs, Universite R. Rabelais, Tours, and fUnit of Nutrition and Cancer, International Agency for Research on Cancer, Lyon, France; gNational Cancer Institute Regina Elena, Rome, Italy

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/26/2004
Accepted: 4/18/2005
Published online: 2/27/2006

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 4

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

Background/Aims: In a cross-sectional study, we investigated the relationship between erythrocyte membrane phospholipid fatty acid composition and dietary fat; we also investigated roles of menopausal status, age, body mass index (BMI) and waist-to-hip ratio (WHR) in interindividual variation of the biomarker. Methods: Study participants were 204 women, aged 39–65 years, drawn from the ORDET cohort and selected as controls in a study of breast cancer. Membrane composition was assessed using capillary gas chromatography. Dietary fat composition was evaluated using a food frequency questionnaire. Results: In pre- and postmenopausal women, erythrocyte membrane phospholipid levels of linoleic acid, oleic acid, and mono-unsaturated fatty acids were significantly associated with corresponding dietary measures (partial correlation coefficients: 0.23 and 0.39; 0.45 and 0.47; 0.40 and 0.48; respectively, in pre- and postmenopausal women). Among postmenopausal women, membrane poly-unsaturated fatty acids were correlated with the corresponding dietary measure (r = 0.39, p < 0.001). Membrane eicosapentanoic and docosahexanoic acid levels were significantly correlated with intake of fish/shell fish : r = 0.21 and r = 0.43 (premenopausal), and r = 0.41 and r = 0.44 (postmenopausal). Age, BMI and WHR had independent effects on membrane lipid composition. Age was associated with delta-6 desaturase activity in postmenopausal women (r = 0.25, p < 0.05). BMI was negatively associated with delta-9 desaturase activity in both pre- and postmenopausal women (r = –0.29, p = 0.01 and r = –0.22, p < 0.01, respectively). WHR was negatively associated with delta-5 desaturase activity in pre-menopausal women (r = –024, p < 0.05). Conclusions: Erythrocyte membrane levels of some specific fatty acids can be used as biomarkers of these fatty acids as proportions of dietary fat.


  

Author Contacts

Dr. P. Muti
Department of Social and Preventive Medicine
270 Farber Hall, SUNY Buffalo
Buffalo, NY 14214 (USA)
Tel. +1 716 829 2975, Fax +1 716 829 2979, E-Mail muti@buffalo.edu

  

Article Information

Received: November 26, 2004
Accepted: April 18, 2005
Published online: December 21, 2005
Number of Print Pages : 8
Number of Figures : 1, Number of Tables : 4, Number of References : 22

  

Publication Details

Annals of Nutrition and Metabolism (European Journal of Nutrition, Metabolic Diseases and Dietetics)

Vol. 50, No. 2, Year 2006 (Cover Date: February 2006)

Journal Editor: Elmadfa, I. (Vienna)
ISSN: 0250–6807 (print), 1421–9697 (Online)

For additional information: http://www.karger.com/ANM


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/26/2004
Accepted: 4/18/2005
Published online: 2/27/2006

Number of Print Pages: 8
Number of Figures: 1
Number of Tables: 4

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.