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Vol. 21, No. 3, 2006
Issue release date: February 2006
Section title: Original Paper
Cerebrovasc Dis 2006;21:166–172
(DOI:10.1159/000090528)

Hypoxaemia in Acute Stroke Is Frequent and Worsens Outcome

Rowat A.M. · Dennis M.S. · Wardlaw J.M.
Division of Clinical Neurosciences, University of Edinburgh, Western General Hospital, Edinburgh, Scotland, UK

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/29/2005
Accepted: 9/21/2005
Published online: 2/24/2006

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Background: Hypoxaemia in the acute phase of stroke might damage the ischaemic penumbra and worsen clinical outcome. We determined the frequency of hypoxaemia on admission with stroke and assessed whether it was related to outcome. Methods: We measured arterial oxygen saturation (SaO2) and breathing effort with portable monitoring equipment in a large cohort of acute stroke patients, continually from arrival at hospital, during interdepartment transfer, in imaging and on the ward. Patients received best medical care according to current guidelines. Baseline neurological examination and 3-month outcome (Modified Rankin Scale) were assessed blind to other data. Hypoxaemia was defined as SaO2 <90% for ≧10% of each assessment stage. Results: Mean SaO2 was lowest during transfers (p < 0.01), but hypoxaemia was common in all assessment stages. Patients with hypoxaemia (30/153, 20%) were more likely to have a pre-existing respiratory disease on admission than those without hypoxaemia (p < 0.04). More patients with hypoxaemia (40%) died than those without hypoxaemia (20%) (hazard ratio, 2.0; 95% CI, 1.0–4.1), though after adjusting for National Institute of Health Stroke Scale and age this association was not statistically significant (hazard ratio, 1.5; 95% CI, 0.7–3.1). There were similar numbers of dependent survivors in both groups. Conclusion: Hypoxaemia during acute stroke assessment was associated with increased risk of death. Although SaO2 is lower during transfers, hypoxaemia occurs in all stages of the admission process. Further research is necessary to determine whether strategies to avoid hypoxaemia during acute assessment improve stroke survival.


  

Author Contacts

Anne M. Rowat
School of Acute and Continuing Care Nursing
Faculty of Health and Life Sciences, Napier University
Canaan Lane Campus, Edinburgh, EH9 2TB (UK)
Tel. +44 131 455 5670, Fax +44 131 455 5638, E-Mail a.rowat@napier.ac.uk

  

Article Information

Received: April 29, 2005
Accepted: September 21, 2005
Published online: December 23, 2005
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 2, Number of References : 19

  

Publication Details

Cerebrovascular Diseases

Vol. 21, No. 3, Year 2006 (Cover Date: February 2006)

Journal Editor: Bogousslavsky, J. (Lausanne)
ISSN: 1015–9770 (print), 1421–9786 (Online)

For additional information: http://www.karger.com/CED


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/29/2005
Accepted: 9/21/2005
Published online: 2/24/2006

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 2

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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