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Vol. 53, No. 1, 2006
Issue release date: February 2006
Section title: Original Paper
Neuropsychobiology 2006;53:46–50
(DOI:10.1159/000090703)

Dopamine Receptor D1 Gene –48A/G Polymorphism Is Associated with Bipolar Illness but Not with Schizophrenia in a Polish Population

Dmitrzak-Weglarz M. · Rybakowski J.K. · Slopien A. · Czerski P.M. · Leszczynska-Rodziewicz A. · Kapelski P. · Kaczmarkiewicz-Fass M. · Hauser J.
aLaboratory of Psychiatric Genetics, Department of Psychiatry, bDepartment of Adult Psychiatry, and cDepartment of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/26/2005
Accepted: 11/6/2005
Published online: 2/10/2006

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

Dysregulation of dopaminergic neurotransmission has been implicated in the etiology of major psychoses. The dopamine D1 receptor (DRD1) plays a role in some brain functions and mechanisms of psychotropic drugs. Therefore, the DRD1 gene makes a good candidate gene for molecular genetic studies in schizophrenia and bipolar affective disorder. In the present study, the –48A/G polymorphism of the DRD1 gene was estimated in patients with schizophrenia (n = 407) or bipolar affective disorder (n = 380), and in healthy controls (n = 399). No association was found between the polymorphism studied and schizophrenia, either in the whole group of patients or in subgroups divided by gender, age at onset or predominance of positive or negative symptoms. A statistical trend was obtained for an association between this polymorphism and bipolar affective disorder (p = 0.059 for genotypes, p = 0.073 for alleles). The G/G genotype and G allele were significantly more frequent in patients with bipolar disorder, type II (p = 0.016 for genotypes, p = 0.008 for alleles), especially in the women subgroup (p = 0.054 for genotypes, p = 0.024 for alleles). An association between the G/G genotype and bipolar affective disorder with disease onset after 18 years of age was also found (p = 0.022). These data suggest that the –48A/G polymorphism of the DRD1 gene may be involved in the etiology of bipolar disorder in a Polish population.


  

Author Contacts

Monika Dmitrzak-Weglarz
Laboratory of Psychiatric Genetics, Department of Psychiatry
Poznan University of Medical Sciences, ul. Szpitalna 27/33
PL–60-572 Poznan (Poland)
Tel. +48 61 8491311, Fax +48 61 8480392, E-Mail mweglarz2003@yahoo.com

  

Article Information

Received: April 26, 2005
Accepted: November 6, 2005
Published online: January 4, 2006
Number of Print Pages : 5
Number of Figures : 0, Number of Tables : 1, Number of References : 24

  

Publication Details

Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)

Vol. 53, No. 1, Year 2006 (Cover Date: February 2006)

Journal Editor: Strik, W. (Bern)
ISSN: 0302–282X (print), 1423–0224 (Online)

For additional information: http://www.karger.com/NPS


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 4/26/2005
Accepted: 11/6/2005
Published online: 2/10/2006

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 1

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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