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Vol. 53, No. 1, 2006
Issue release date: February 2006
Section title: Original Paper
Neuropsychobiology 2006;53:51–56
(DOI:10.1159/000090704)

Association Analysis of the GSK-3β T–50C Gene Polymorphism with Schizophrenia and Bipolar Disorder

Szczepankiewicz A. · Skibinska M. · Hauser J. · Slopien A. · Leszczynska-Rodziewicz A. · Kapelski P. · Dmitrzak-Weglarz M. · Czerski P.M. · Rybakowski J.K.
aLaboratory of Psychiatric Genetics, Department of Psychiatry, bDepartment of Adult Psychiatry, and cDepartment of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/17/2005
Accepted: 11/6/2005
Published online: 2/10/2006

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

Abstract

Glycogen synthase kinase-3β (GSK-3β) has been implicated in the pathogenesis of major psychoses. In this paper, the T–50C polymorphism of the GSK-3β gene has been studied in patients with schizophrenia (n = 432), patients with bipolar disorder (n = 416) and in a healthy control group (n = 408). Consensus diagnosis by at least two psychiatrists was made for each patient, according to DSM-IV and ICD-10 criteria, using the Structured Clinical Interview for DSM-IV Axis I Disorders. Genotypes were established by the polymerase chain reaction-restriction fragment length polymorphism method. We have found a trend towards an association for the C allele in the whole group of schizophrenic patients (p = 0.088) and for the heterozygous T/C genotype of bipolar patients (0.095). Significant differences of genotype distribution and allele frequencies of the T–50C polymorphism were found in the female group of bipolar II patients (p = 0.015 for genotypes and p = 0.009 for alleles). In conclusion, this polymorphism may be associated with female gender in bipolar II disorder.


  

Author Contacts

Aleksandra Szczepankiewicz
Laboratory of Psychiatric Genetics, Department of Adult Psychiatry
University of Medical Sciences, ul. Szpitalna 27/33
PL–60-572 Poznan (Poland)
Tel. +48 61 849 1311, Fax +48 61 848 0392, E-Mail alszczep@amp.edu.pl

  

Article Information

Received: February 17, 2005
Accepted: November 6, 2005
Published online: January 4, 2006
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 3, Number of References : 27

  

Publication Details

Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)

Vol. 53, No. 1, Year 2006 (Cover Date: February 2006)

Journal Editor: Strik, W. (Bern)
ISSN: 0302–282X (print), 1423–0224 (Online)

For additional information: http://www.karger.com/NPS


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/17/2005
Accepted: 11/6/2005
Published online: 2/10/2006

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 3

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS


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