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Vol. 50, No. 3, 2006
Issue release date: May 2006
Section title: Original Paper
Ann Nutr Metab 2006;50:167–172
(DOI:10.1159/000090736)

Bioavailability of Apigenin from Apiin-Rich Parsley in Humans

Meyer H. · Bolarinwa A. · Wolfram G. · Linseisen J.
aUnit of Human Nutrition and Cancer Prevention and bDepartment of Food and Nutrition, Technical University of Munich, Freising-Weihenstephan, and cDivision of Clinical Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/31/2005
Accepted: 9/8/2005
Published online: 6/1/2006

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 2

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM

Abstract

Aim: Absorption and excretion of apigenin after the ingestion of apiin-rich food, i.e. parsley, was tested. Methods: Eleven healthy subjects (5 women, 6 men) in the age range of 23–41 years and with an average body mass index of 23.9 ± 4.1 kg/m2 took part in this study. After an apigenin- and luteolin-free diet, a single oral bolus of 2 g blanched parsley (corresponding to 65.8 ± 15.5 µmol apigenin) per kilogram body weight was consumed. Blood samples were taken at 0, 4, 6, 7, 8, 9, 10, 11 and 28 h after parsley consumption and 24-hour urine samples were collected. Apigenin was analyzed in plasma, urine and red blood cells by means of HPLC-ECD. Results: On average, a maximum apigenin plasma concentration of 127 ± 81 nmol/l was reached after 7.2 ± 1.3 h with a high range of variation between subjects. For all participants, plasma apigenin concentration rose after bolus ingestion and fell within 28 h under the detection limit (2.3 nmol/l). The average apigenin content in 24-hour urine was 144 ± 110 nmol/24 h corresponding to 0.22 ± 0.16% of the ingested dose. The flavone could be detected in red blood cells without showing dose-response characteristics. Conclusions: A small portion of apigenin provided by food reaches the human circulation and, therefore, may reveal biological effects.


  

Author Contacts

Dr. Jakob Linseisen, PD
Deutsches Krebsforschungszentrum, Department of Clinical Epidemiology
Im Neuenheimer Feld 280, DE–69120 Heidelberg (Germany)
Tel. +49 6221 422362, Fax +49 6221 422203
E-Mail j.linseisen@dkfz.de

  

Article Information

Received: January 31, 2005
Accepted: September 8, 2005
Published online: January 10, 2006
Number of Print Pages : 6
Number of Figures : 3, Number of Tables : 2, Number of References : 22

  

Publication Details

Annals of Nutrition and Metabolism (European Journal of Nutrition, Metabolic Diseases and Dietetics)

Vol. 50, No. 3, Year 2006 (Cover Date: May 2006)

Journal Editor: Elmadfa, I. (Vienna)
ISSN: 0250–6807 (print), 1421–9697 (Online)

For additional information: http://www.karger.com/ANM


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 1/31/2005
Accepted: 9/8/2005
Published online: 6/1/2006

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 2

ISSN: 0250-6807 (Print)
eISSN: 1421-9697 (Online)

For additional information: http://www.karger.com/ANM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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