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Table of Contents
Vol. 28, No. 1-2, 2006
Issue release date: February 2006
Section title: Original Paper
Dev Neurosci 2006;28:49–57
(DOI:10.1159/000090752)

Loss of Notch Activity in the Developing Central Nervous System Leads to Increased Cell Death

Mason H.A.a · Rakowiecki S.M.a · Gridley T.b · Fishell G.a
aDevelopmental Genetics Program and the Department of Cell Biology, The Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, N.Y., and bThe Jackson Laboratory, Bar Harbor, Me., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 27, 2005
Accepted: August 08, 2005
Published online: March 03, 2006
Issue release date: February 2006

Number of Print Pages: 9
Number of Figures: 5
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE

Abstract

Many cells in the mammalian brain undergo apoptosis as a normal and critical part of development but the signals that regulate the survival and death of neural progenitor cells and the neurons they produce are not well understood. The Notch signaling pathway is involved in multiple decision points during development and has been proposed to regulate the survival and apoptosis of neural progenitor cells in the developing brain; however, previous experiments have not resolved whether Notch activity is pro- or anti-apoptotic. To elucidate the function of Notch signaling in the survival and death of cells in the nervous system, we have produced single and compound Notch conditional mutants in which Notch1 and Notch3 are removed at different times during brain development and in different populations of cells. We show here that a large number of neural progenitor cells, as well as differentiating neurons, undergo apoptosis in the absence of Notch1 and Notch3, suggesting that Notch activity promotes the survival of both progenitors and newly differentiating cells in the developing nervous system. Finally, we show that postmitotic neurons do not require Notch activity indefinitely to regulate their survival since elevated levels of cell death are observed only during embryogenesis in the Notch mutants and are not detected in neonates.

© 2006 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 27, 2005
Accepted: August 08, 2005
Published online: March 03, 2006
Issue release date: February 2006

Number of Print Pages: 9
Number of Figures: 5
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE


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