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Vol. 28, No. 1-2, 2006
Issue release date: February 2006
Section title: Original Paper
Dev Neurosci 2006;28:128–141
(DOI:10.1159/000090759)

Notch Activity Is Downregulated Just prior to Retinal Ganglion Cell Differentiation

Nelson B.R.a · Gumuscu B.a · Hartman B.H.b · Reh T.A.a
aDepartment of Biological Structure, and bDepartment of Physiology and Biophysics, University of Washington, Seattle, Wash., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/7/2005
Accepted: 4/12/2005
Published online: 3/3/2006
Issue release date: February 2006

Number of Print Pages: 14
Number of Figures: 7
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE

Abstract

The Notch signaling pathway is important at several stages of retinal development including the differentiation of retinal ganglion cells and Müller glia. The downstream effectors of Notch signaling, Hes1 and Hes5, have been shown to be critical in the retina as well. While Notch activity directly regulates Hes1 and Hes5 elsewhere in the nervous system, it has been unclear whether Hes1 and/or Hes5 are directly regulated by Notch activity in the developing retina. Here, we report that both Hes1 and Hes5 are directly regulated by Notch activity during retinal development. Using fluorescence-based Hes1 and Hes5 reporter constructs, we can monitor Notch activity in progenitor cells in the intact retina, and we find that Notch activity is downregulated just prior to retinal ganglion cell differentiation.

© 2006 S. Karger AG, Basel


  

Author Contacts

Dr. T.A. Reh
Department of Biological Structure, Box 357420
University of Washington
Seattle, WA 98195 (USA)
Tel. +1 206 543 8043, Fax +1 206 543 1524, E-Mail tomreh@u.washington.edu

  

Article Information

Received: February 7, 2005
Accepted: April 12, 2005
Number of Print Pages : 14
Number of Figures : 7, Number of Tables : 0, Number of References : 47

  

Publication Details

Developmental Neuroscience

Vol. 28, No. 1-2, Year 2006 (Cover Date: February 2006)

Journal Editor: Campagnoni, A.T. (Los Angeles, Calif.)
ISSN: 0378–5866 (print), 1421–9859 (Online)

For additional information: http://www.karger.com/DNE


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 2/7/2005
Accepted: 4/12/2005
Published online: 3/3/2006
Issue release date: February 2006

Number of Print Pages: 14
Number of Figures: 7
Number of Tables: 0

ISSN: 0378-5866 (Print)
eISSN: 1421-9859 (Online)

For additional information: http://www.karger.com/DNE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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