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Original Research Article

Free Access

Functional Vitamin E Deficiency in ApoE4 Patients with Alzheimer’s Disease

Mas E.a-c · Dupuy A.M.a, b · Artero S.b · Portet F.b, c · Cristol J.P.a · Ritchie K.b · Touchon J.b, c

Author affiliations

aDepartment of Biochemistry, Lapeyronie Hospital, bINSERM, Unit E361, Epidemiology of Neurodegenerative Pathologies of the Nervous System, cDepartment of Neurology, Gui de Chauliac Hospital, Montpellier, France

Corresponding Author

J.P. Cristol

Department of Biochemistry, Hôpital Lapeyronie

191 Avenue du Doyen Gaston Giraud

FR–34295 Montpellier Cédex 5 (France)

Tel. +33 467 338 345, Fax +33 467 338 393, E-Mail jp-cristol@chu-montpellier.fr

Related Articles for ""

Dement Geriatr Cogn Disord 2006;21:198–204

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Abstract

Oxidative stress has been implicated in the development of Alzheimer’s disease (AD). Consequently, antioxidant therapies including Vitamin E (VitE) supplementation for both prevention and treatment of neurodegenerative diseases currently appears to be a promising avenue of research. The aim of the present study was to examine the relationship between AD and the ApoE phenotype, lipid parameters and VitE levels in a large cohort of elderly subjects. No absolute deficit was observed in plasma VitE levels. However in AD, ApoE4 is not associated with an increase in total cholesterol (TC) and VitE levels. Moreover, our results suggest that oxidative stress-induced injury and protection by VitE in AD are related to the ApoE phenotype. Our study strongly supports the hypothesis of an impairment of lipophilic antioxidant delivery to neuronal cells in AD leading to a tissular antioxidant deficiency which could facilitate oxidative stress.

© 2006 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: September 28, 2005
Published online: February 06, 2006
Issue release date: February 2006

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 2

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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