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Vol. 115, No. 3-4, 2006
Issue release date: March 2006
Section title: Paper
Acta Haematol 2006;115:207–213
(DOI:10.1159/000090937)

Postthrombotic Syndrome in Children

Manco-Johnson M.J.
Mountain States Regional Hemophilia and Thrombosis Center, Department of Pediatrics, University of Colorado Health Sciences Center and The Children’s Hospital, Denver, Colo., USA

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 3/17/2006

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 2

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA

Abstract

The postthrombotic syndrome (PTS) is a clinical condition of limb pain along with physical findings that range from swelling to stasis ulcers following one or more episodes of deep vein thrombosis (DVT). While venous thromboembolism has recently gained increased recognition in children, the sequelae of limb thrombi are being recognized in a substantial proportion of affected children, and with varying degrees of severity. PTS is caused by both obstructed as well as refluxed venous blood flow, with combined effects of obstruction and reflux resulting in earlier, and more extensive symptoms. PTS can be diagnosed using an evaluation tool adapted from an international adult scale. Certain risk factors predispose children to PTS including elevations in factor VIII activity and D-dimer, clot occlusiveness, clot persistence, number of venous segments involved and duration of observation following DVT. Optimal prevention and treatment have not yet been determined, although antithrombotic therapy to facilitate rapid clot resolution, elevation, compression, moderate exercise and achievement of optimal body weight are likely to improve outcome.


  

Author Contacts

Marilyn J. Manco-Johnson, MD
Mountain States Regional Hemophilia and Thrombosis Center
PO Box 6507, Mail Stop F-416
Aurora, CO 80045-0507 (USA)
Tel. +1 303 724 0365, Fax +1 303 724 0947, E-Mail marilyn.manco-johnson@uchsc.edu

  

Article Information

Number of Print Pages : 7
Number of Figures : 3, Number of Tables : 2, Number of References : 29

  

Publication Details

Acta Haematologica

Vol. 115, No. 3-4, Year 2006 (Cover Date: March 2006)

Journal Editor: Ben-Bassat, I. (Tel Hashomer)
ISSN: 0001–5792 (print), 1421–9662 (Online)

For additional information: http://www.karger.com/AHA


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 3/17/2006

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 2

ISSN: 0001-5792 (Print)
eISSN: 1421-9662 (Online)

For additional information: http://www.karger.com/AHA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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