Post-Operative Delirium Is Associated with Poor Cognitive Outcome and DementiaWacker P. · Nunes P.V. · Cabrita H. · Forlenza O.V.
aLaboratory of Neuroscience (LIM-27), Department and Institute of Psychiatry, and bInstitute of Orthopaedics, Faculty of Medicine, University of Sao Paulo, Sao Paulo, Brazil
The objective of the present study is to evaluate the association between the occurrence of delirium and the cognitive outcome in elderly subjects. Hospital files of 572 patients who underwent hip or knee replacement between 1998 and 2004 were examined. A sample of 90 elderly subjects (31 with evidence of post-operative delirium), non-demented at baseline, was screened for cognitive decline and dementia. Diagnosis of dementia was highly associated with the occurrence of delirium. The relative risk for the diagnosis of dementia among subjects with previous history of delirium, according to the IQcode screening, was 10.5 (95% CI: 3.3–33.2). Such patients had a significantly higher mean IQcode score (3.75) as compared to controls (3.1; p < 0.001). Cognitive functions most affected in these patients were memory, orientation and abstract thinking. We conclude that the occurrence of post-operative delirium in cognitively unimpaired elderly subjects is associated with a worse cognitive outcome and an increased risk of dementia.
Orestes V. Forlenza, Laboratório de Neurociências – LIM 27
Instituto de Psiquiatria do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
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Accepted: September 28, 2005
Published online: January 18, 2006
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 3, Number of References : 28
Dementia and Geriatric Cognitive Disorders
Vol. 21, No. 4, Year 2006 (Cover Date: April 2006)
Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)
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