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Variation in Mineral Properties in Normal and Mutant Bones and Teeth

Boskey A.L.a · Young M.F.b · Kilts T.b · Verdelis K.a

Author affiliations

aMineralized Tissue Research Laboratory, Musculoskeletal Integrity Program, Hospital for Special Surgery, New York, N.Y., and bNational Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Md., USA

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Cells Tissues Organs 2005;181:144–153

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: April 18, 2006
Issue release date: April 2006

Number of Print Pages: 10
Number of Figures: 5
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO

Abstract

Hydroxyapatite mineral is deposited in an organized fashion in the matrices of bones and teeth. The amount of mineral present, the composition of the mineral, and the size of the mineral crystals varies with both tissue and animal age, diet, health status, and the tissue being examined. Here, we review methods for measuring these differences in mineral properties and provide some illustrations from bones and teeth of animals in which the small leucine-rich proteoglycans (biglycan and decorin) were ablated. Differences in mineral properties between biglycan-deficient bones and teeth are related to the functions of this small proteoglycan in these tissues.

© 2005 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: April 18, 2006
Issue release date: April 2006

Number of Print Pages: 10
Number of Figures: 5
Number of Tables: 0

ISSN: 1422-6405 (Print)
eISSN: 1422-6421 (Online)

For additional information: http://www.karger.com/CTO


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