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Original Paper

Clinicopathologic Characteristics of Hepatitis C Virus-Associated Intrahepatic Cholangiocarcinoma

Hai S.a · Kubo S.a · Yamamoto S.a · Uenishi T.a · Tanaka H.a · Shuto T.a · Takemura S.a · Yamazaki O.b · Hirohashi K.a

Author affiliations

aDepartment of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate School of Medicine, and bDepartment of Gastrointestinal Surgery, Osaka City General Hospital, Osaka, Japan

Related Articles for ""

Dig Surg 2005;22:432–439

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 16, 2005
Accepted: November 09, 2005
Published online: April 21, 2006
Issue release date: April 2006

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 7

ISSN: 0253-4886 (Print)
eISSN: 1421-9883 (Online)

For additional information: http://www.karger.com/DSU

Abstract

Background: Although hepatitis C virus (HCV) infection is a possible pathogenetic factor for intrahepatic cholangiocarcinoma (ICC), clinicopathologic features of ICC patients with HCV infection remain unclear. Patients and Methods: Of 50 patients with ICC treated, 19 were infected with HCV (HCV-positive group) and 38 underwent surgical treatment. Clinicopathologic features and postoperative outcome were compared between patients with and without HCV infection. Results: In 15 patients in the HCV-positive group, ICC was detected during follow-up for chronic hepatitis C. The proportion of patients who underwent curative resection was significantly higher in the HCV-positive than in the HCV-negative group, and tumors were significantly smaller in the HCV-positive than in the HCV-negative group. In the HCV-positive group, tumors were significantly smaller in patients who were followed up for chronic hepatitis C than in patients who were not followed up. Although cumulative survival rates did not differ significantly between groups, prognoses of patients with small ICC were significantly better than those with large ICC. Conclusion: Follow-up for patients with chronic hepatitis C by imaging series at regular intervals is important and provides the possibility to detect a small ICC as well as a hepatocellular carcinoma. Resection should be guided by liver function and the tumor stage in patients with HCV-associated ICC.

© 2005 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 16, 2005
Accepted: November 09, 2005
Published online: April 21, 2006
Issue release date: April 2006

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 7

ISSN: 0253-4886 (Print)
eISSN: 1421-9883 (Online)

For additional information: http://www.karger.com/DSU


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