Hormonal Regulation of Postnatal Growth in Children Born Small for Gestational AgeCianfarani S. · Ladaki C. · Geremia C.
‘Rina Balducci’ Centre of Paediatric Endocrinology, Department of Public Health and Cell Biology, Tor Vergata University, Rome, Italy
Children born small for gestational age (SGA) are at high risk of permanent short stature, with approximately 10% continuing to have stature below the third centile throughout childhood and adolescence and into adulthood. The mechanisms involved in catch-up growth, and those that prevent catch-up growth, are still unknown. To date, no reliable anthropometric or endocrine parameter predictive of postnatal catch-up growth has been identified. However, subtle abnormalities in the growth hormone-insulin-like growth factor axis, the hypothalamic-pituitary-adrenal axis and thyroid function have been described, and a mechanism involving intrauterine programming of hypothalamic-pituitary function has been proposed.
‘Rina Balducci’ Centre of Paediatric Endocrinology
Department of Public Health and Cell Biology, Room E-178
Tor Vergata University, Via Montpellier 1, IT–00133 Rome (Italy)
Tel. +39 06 5100 2314, Fax +39 06 5917 415, E-Mail firstname.lastname@example.org
Published online: April 10, 2006
Number of Print Pages : 5
Number of Figures : 3, Number of Tables : 0, Number of References : 30
Hormone Research (From Developmental Endocrinology to Clinical Research)
Vol. 65, No. Suppl. 3, Year 2006 (Cover Date: April 2006)
Journal Editor: Czernichow, P. (Paris)
ISSN: 0301–0163 (print), 1423–0046 (Online)
For additional information: http://www.karger.com/HRE