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Table of Contents
Vol. 139, No. 4, 2006
Issue release date: March 2006
Section title: Original Paper
Int Arch Allergy Immunol 2006;139:294–298
(DOI:10.1159/000091600)

Traffic-Related Air Pollutants Induce the Release of Allergen-Containing Cytoplasmic Granules from Grass Pollen

Motta A.C.a · Marliere M.c · Peltre G.d · Sterenberg P.A.b · Lacroix G.c
aLaboratory of Allergology and Pulmonary Diseases, Department of Pathology and Laboratory Medicine, Groningen University Medical Center, Groningen University, Groningen, and bNational Institute of Public Health and the Environment, Bilthoven, The Netherlands; cInstitut National de l’Environnement Industriel et des Risques, Verneuil-en-Halatte, and dESPCI Laboratoire Environnement et Chimie Analytique, Allergie et Environnement, Paris, France

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 04, 2005
Accepted: December 20, 2005
Published online: March 31, 2006
Issue release date: March 2006

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background/Aim: Pollen cytoplasmic granules (PCG) are loaded with allergens. They are released from grass pollen grains following contact with water and can form a respirable allergenic aerosol. On the other hand, the traffic-related air pollutants NO2 and O3 are known to be involved in the current increase in the prevalence of allergic diseases via their adjuvant effects. Our objective was to determine the effects of air pollutants on the release of PCG from Phleum pratense (timothy grass) pollen. Methods:P. pratense pollen was exposed to several concentrations of NO2 and O3. The induced morphological damages were observed by environmental scanning electron microscopy, and the amount of PCG released from the pollen upon contact with water was measured. Results: The percentages of damaged grain were 6.4% in air-treated controls, 15% after treatment with the highest NO2 dose (50 ppm) and 13.5% after exposure to 0.5 ppm O3. In treated samples, a fraction of the grains spontaneously released their PCG. Upon subsequent contact with water, the remaining intact grains released more PCG than pollen exposed to air only. Conclusions: Traffic-related pollutants can trigger the release of allergen-containing granules from grass pollen, and increase the bioavailability of airborne pollen allergens. This is a new mechanism by which air pollution concurs with the current increase in the prevalence of allergic diseases.

© 2006 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 04, 2005
Accepted: December 20, 2005
Published online: March 31, 2006
Issue release date: March 2006

Number of Print Pages: 5
Number of Figures: 3
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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