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Vol. 76, No. 3, 2006
Issue release date: April 2006
Section title: Original Paper
Urol Int 2006;76:202–208
(DOI:10.1159/000091619)

Clinical and Pathological Characteristics of Patients Presenting with Biochemical Progression after Radical Retropubic Prostatectomy for Pathologically Organ-Confined Prostate Cancer

Pinto F.a · Prayer-Galetti T.a · Gardiman M.b · Sacco E.a · Ciaccia M.a · Fracalanza S.a · Betto G.a · Pagano F.a
Departments of aUrology and bPathology, School of Medicine, Padua, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/15/2005
Accepted: 11/9/2005
Published online: 4/6/2006
Issue release date: April 2006

Number of Print Pages: 7
Number of Figures: 5
Number of Tables: 3

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

Abstract

Introduction: To identify risk factors for biochemical failure after radical prostatectomy (RP) in men with pathologically organ-confined (OC) prostate cancer (PCa). Materials and Methods: Clinical and pathological features of 350 consecutive patients with pathologically OC PCa treated only with RP and bilateral pelvic lymphadenectomy were analyzed, retrospectively, to identify predictor parameters of prostate-specific antigen (PSA) failure (PSA ≧0.4 ng/ml). The median follow-up was 58.6 months (range: 3.9–183 months). All pathological specimens were step sectioned at 4-mm intervals. Kaplan-Meier progression-free survival rates and χ2 test were adopted for statistical analyses. Multivariate Cox proportional hazard regression models were used to test the association between pathological Gleason score and surgical margin status. Results: 67 patients (19.1%) failed at a median follow-up of 40.2 months (range 1.9–123.3). Age and preoperative PSA failed to reveal significance also in patients with serum PSA ≧20 ng/ml (p = 0.46). Patients with T3 clinical stage had a higher progression rate compared to T1C and T2 (43.5 vs. 27.8 and 17.3%, respectively) even if no high statistical significance was pointed out. Presence of perineural infiltration (p = 0.04) and prostatic apex infiltration (p = 0.74) in the prostatectomy specimens failed to reveal significance. A high pathological Gleason score (≧7; p = 0.0003) and surgical margin status (p < 0.0001) were shown to be the most powerful predictive parameters of biochemical progression. Conclusions: In patients with pathologically OC PCa the presence of a high pathological Gleason score and positive surgical margins appear to represent the most important factors for prediction of outcome following RP.

© 2006 S. Karger AG, Basel


  

Author Contacts

Dr. Simonetta Fracalanza
Dip. Scienze Oncol. e Chirurg., Sezione Clinica Urologica
Monoblocco Ospedaliero, Via Giustiniani 2
IT–35100 Padova (Italy)
Tel. +39 049 821 2724, Fax +39 049 821 2721, E-Mail simonetta.fracalanza@unipd.it

  

Article Information

Received: July 15, 2005
Accepted: November 9, 2005
Number of Print Pages : 7
Number of Figures : 5, Number of Tables : 3, Number of References : 26

  

Publication Details

Urologia Internationalis

Vol. 76, No. 3, Year 2006 (Cover Date: April 2006)

Journal Editor: Hakenberg, O.W. (Dresden)
ISSN: 0042–1138 (print), 1423–0399 (Online)

For additional information: http://www.karger.com/UIN


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 7/15/2005
Accepted: 11/9/2005
Published online: 4/6/2006
Issue release date: April 2006

Number of Print Pages: 7
Number of Figures: 5
Number of Tables: 3

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


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