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Vol. 26, No. 1, 2006
Issue release date: April 2006
Section title: Original Report: Laboratory Investigation
Am J Nephrol 2006;26:43–49
(DOI:10.1159/000091785)

Tandem Repeats Polymorphism of MUC20 Is an Independent Factor for the Progression of Immunoglobulin A Nephropathy

Li G. · Zhang H. · Lv J. · Hou P. · Wang H.
Renal Division, Peking University First Hospital, Peking University Institute of Nephrology, Beijing, China

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Article / Publication Details

First-Page Preview
Abstract of Original Report: Laboratory Investigation

Received: 12/4/2005
Accepted: 1/18/2006
Published online: 4/5/2006
Issue release date: April 2006

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 4

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN

Abstract

MUC20, an upregulated novel gene in the renal tissues of patients with IgA nephropathy (IgAN), was recently identified. The variable number of tandem repeats (VNTR) polymorphism of the MUC20 gene was detected in several cell lines. In the present study, we investigated a possible association of MUC20 VNTR polymorphism with the clinical manifestations and progression in patients with IgAN. A total of 1,147 Chinese subjects, including 657 patients with IgAN and 490 geographically matched healthy controls, were involved in this investigation. One hundred and thirty-seven patients had been followed up for 60.6 ± 22.4 months. MUC20 VNTR polymorphism was genotyped by polymerase chain reaction amplification and confirmed by sequencing. The alleles were divided into two groups according to the repeat times of MUC20 VNTR, i.e. small alleles (VNTR repeat times ≤3) and large alleles (VNTR repeat times >3), and the genotypes of subjects were classified into SS, SL and LL groups. The frequencies of the alleles and genotypes of MUC20 VNTR polymorphisms did not differ between patients with IgAN and healthy controls. Additionally, there was no significant difference in the clinical features. Furthermore, IgAN patients with SL/LL genotypes had a higher risk of decline in renal function (odds ratio 20.9; 95% confidence interval 2.6–168.1; p = 0.004) than those with SS genotypes. The present study revealed that there is no association between the VNTR polymorphism of the MUC20 gene and the clinical manifestations in IgAN patients at the time of renal biopsy. However, IgAN patients with SL/LL genotypes had a higher risk of the progression to end-stage renal disease.

© 2006 S. Karger AG, Basel


  

Author Contacts

Hong Zhang, MD, PhD
Renal Division, Peking University First Hospital
Peking University Institute of Nephrology
Beijing 100034 (China)
Tel. +86 10 6655 1122, ext. 2388, Fax +86 10 6655 1055, E-Mail hongzh@bjmu.edu.cn

  

Article Information

Received: December 4, 2005
Accepted: January 18, 2006
Published online: February 24, 2006
Number of Print Pages : 7
Number of Figures : 4, Number of Tables : 4, Number of References : 25

  

Publication Details

American Journal of Nephrology

Vol. 26, No. 1, Year 2006 (Cover Date: April 2006)

Journal Editor: Bakris, G. (Chicago, Ill.)
ISSN: 0250–8095 (print), 1421–9670 (Online)

For additional information: http://www.karger.com/AJN


Article / Publication Details

First-Page Preview
Abstract of Original Report: Laboratory Investigation

Received: 12/4/2005
Accepted: 1/18/2006
Published online: 4/5/2006
Issue release date: April 2006

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 4

ISSN: 0250-8095 (Print)
eISSN: 1421-9670 (Online)

For additional information: http://www.karger.com/AJN


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