Physiological Response to Superantigen-Adsorbing Hemoperfusion in Toxin-Concentration-Controlled Septic SwineMiwa K.a · Fukuyama M.b · Matsuno N.c · Shimada K.b · Ikeda K.d · Ikeda T.d
aNew Frontiers Research Laboratories, Toray Industries, Inc., Kanagawa; bSpecialty Material Research Laboratories, Toray Industries Inc., Shiga; cFifth Department of Surgery, Hachioji Medical Center, Tokyo Medical University, and dDivision of Critical Care and Emergency Medicine, Hachioji Medical Center, Tokyo Medical University, Tokyo, Japan
Background/Aims: Superantigens are suspected of being potent initiators of gram-positive sepsis, and new therapies for superantigen elimination are required. The effects of hemoadsorption with a superantigen-adsorbing device (SAAD) were evaluated in septic swine. Methods: Toxic shock syndrome toxin-1 (TSST-1) was infused, and blood concentration was maintained at the clinical level for 6 h. Endotoxin was then infused to induce lethal shock. All animals were hemoperfused with SAAD or a control column for 8 h and changes in pathological parameters and mortality were examined. Results: Animals perfused with SAAD had a highly significant (p < 0.01) survival advantage compared with control groups at 24 h after initiation of the TSST-1 infusion. SAAD also suppressed the increase in the arteriovenous shunt ratio and decrease of partial arterial oxygen pressure at 6 h after TSST-1 infusion initiation. Conclusion: We suggest that there is a potential application of SAAD in treating superantigen-induced respiratory dysfunction and sepsis.
Keishi Miwa, MD
New Frontiers Research Laboratories, Toray Industries, Inc.
1111, Tebiro, Kamakura
Kanagawa 248-8555 (Japan)
Tel. +81 467 32 9265, Fax +81 467 32 8363, E-Mail Keishi_Miwa@nts.toray.co.jp
The work was conducted in Hachioji Medical Center, Tokyo Medical University.
Received: July 20, 2005
Accepted: September 8, 2005
Published online: March 3, 2006
Number of Print Pages : 8
Number of Figures : 4, Number of Tables : 1, Number of References : 19
Vol. 24, No. 3, Year 2006 (Cover Date: April 2006)
Journal Editor: Leunissen, K.M.L. (Maastricht)
ISSN: 0253–5068 (print), 1421–9735 (Online)
For additional information: http://www.karger.com/BPU