Orbitofrontal Dysfunction Related to Both Apathy and Disinhibition in Frontotemporal DementiaPeters F. · Perani D. · Herholz K. · Holthoff V. · Beuthien-Baumann B. · Sorbi S. · Pupi A. · Degueldre C. · Lemaire C. · Collette F. · Salmon E.
aCyclotron Research Center, University of Liège, Liège, Belgium; bVita Salute San Raffaele University, and IRCCS H San Raffaele, IBFM-CNR, Milan, Italy; cDepartment of Neurology, University of Cologne, and Max-Planck Institute for Neurological Research, Cologne, dDepartment of Psychiatry and Psychotherapy, Dresden University of Technology, eDepartment of Nuclear Medicine, Dresden University of Technology, and PET Center, Research Center Rossendorf, Dresden, Germany; fDepartment of Neurological and Psychiatric Sciences, University of Florence, gDepartment of Physiopathology, University of Florence, Florence, Italy
Orbitofrontal metabolic impairment is characteristic of the frontal variant of frontotemporal dementia (fv-FTD), as are early changes in emotional and social conduct. Two main types of behavioral disturbances have been distinguished in fv-FTD patients: apathetic and disinhibited manifestations. In this study, we searched for relationships between brain metabolism and presence of apathetic or disinhibited behavior. Metabolic activity and behavioral data were collected in 41 fv-FTD patients from European PET centers. A conjunction analysis of the PET data showed an expected impairment of metabolic activity in the anterior cingulate, ventromedial and orbital prefrontal cortex, the dorsolateral prefrontal cortex and the left anterior insula in fv-FTD subjects compared to matched controls. A correlation was observed between disinhibition scores on the Neuropsychiatric Inventory scale and a cluster of voxels located in the posterior orbitofrontal cortex (6, 28, –24). Comparison of brain activity between apathetic and nonapathetic fv-FTD patients from two centers also revealed a specific involvement of the posterior orbitofrontal cortex in apathetic subjects (4, 22, –22). The results confirm that the main cerebral metabolic impairment in fv-FTD patients affects areas specializing in emotional evaluation and demonstrate that decreased orbitofrontal activity is related to both disinhibited and apathetic syndromes in fv-FTD.
Cyclotron Research Center (Bat. B30), University of Liège
Allée du 6 août 8
BE–4000 Liège (Belgium)
Tel. +32 43 66 23 06, Fax +32 43 66 28 08, E-Mail Frederic.Peters@ulg.ac.be
Accepted: December 14, 2005
Published online: March 7, 2006
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 3, Number of References : 36
Dementia and Geriatric Cognitive Disorders
Vol. 21, No. 5-6, Year 2006 (Cover Date: May 2006)
Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)
For additional information: http://www.karger.com/DEM