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Vol. 90, No. 2, 2006
Issue release date: August 2006
Section title: Original Paper
Biol Neonate 2006;90:89–97
(DOI:10.1159/000092005)

Hyperoxia and Tidal Volume: Independent and Combined Effects on Neonatal Pulmonary Inflammation

Ehlert C.A. · Truog W.E. · Thibeault D.W. · Garg U. · Norberg M. · Rezaiekhaligh M. · Mabry S. · Ekekezie I.I.
aSection of Neonatal-Perinatal Medicine, bSection of Pathology, Department of Pediatrics, Children’s Mercy Hospitals and Clinics, University of Missouri-Kansas City School of Medicine, Kansas City, Mo., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/30/2005
Accepted: 10/24/2005
Published online: 8/10/2006

Number of Print Pages: 9
Number of Figures: 6
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO

Abstract

Background: Hyperoxia and tidal volume mechanical ventilation are independent factors in the genesis of lung injury, but it remains unclear the extent to which each is responsible or contributes to this process in newborns. Objectives: To study the independent and combined effects of hyperoxia and tidal volume mechanical ventilation on the induction of lung inflammation in a newborn piglet model of ventilator-induced lung injury. Methods: Following exposure to either ambient air or FIO2 = 1.0 for a period of 3 days, newborn piglets were randomized to receive mechanical ventilation with either high tidal volume (20 ml/kg) or low tidal volume (6 ml/kg) for 4 h while controlling for pH. Results: Monocyte chemoattractant protein-1 level in the lungs of animals randomized to hyperoxia with high tidal volume ventilation was significantly elevated, compared to all other groups (p < 0.05). Myeloperoxidase assayed in lung homogenate was found to be significantly higher in nonventilated animals exposed to hyperoxia (p < 0.01). Only in animals previously exposed to hyperoxia did the addition of high tidal volume ventilation further increase the level of myeloperoxidase present (p < 0.05). Pulmonary vascular resistance was significantly elevated after 4 h of mechanical ventilation compared to 1 h (p < 0.001). Conclusions: We conclude that in neonatal piglets undergoing hyperoxic stress, superimposition of high tidal volume ventilation exacerbates the lung inflammation as assessed by lung monocyte chemoattractant protein-1 and level of myeloperoxidase.


  

Author Contacts

Carey A. Ehlert, MD
Pediatric Neonatalogy C410, Children’s Corporate Center,
Children’s Hospital of Wisconsin, P.O. Box 1997
Milwaukee, WI 53201-1997 (USA)
Tel. +1 414 266 7583, Fax +1 414 266 6979, E-Mail cehlert@mail.mcw.edu

  

Article Information

Received: May 30, 2005
Accepted after revision: October 24, 2005
Published online: March 14, 2006
Number of Print Pages : 9
Number of Figures : 6, Number of Tables : 2, Number of References : 30

  

Publication Details

Biology of the Neonate (Fetal and Neonatal Research)

Vol. 90, No. 2, Year 2006 (Cover Date: August 2006)

Journal Editor: Halliday, H.L. (Belfast)
ISSN: 0006–3126 (print), 1421–9727 (Online)

For additional information: http://www.karger.com/BON


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/30/2005
Accepted: 10/24/2005
Published online: 8/10/2006

Number of Print Pages: 9
Number of Figures: 6
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: http://www.karger.com/NEO


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