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Vol. 3, No. 1-2, 2006
Issue release date: May 2006
Section title: Signaling and Stem Cells
Neurodegenerative Dis 2006;3:68–75
(DOI:10.1159/000092096)

Erythropoietin and Normal Brain Development: Receptor Expression Determines Multi-Tissue Response

Chen Z.-Y. · Warin R. · Noguchi C.T.
Molecular Cell Biology Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md., USA

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Article / Publication Details

First-Page Preview
Abstract of Signaling and Stem Cells

Published online: 5/17/2006

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 0

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD

Abstract

Erythropoietin (EPO) is a hypoxia-inducible hormone required for erythroid differentiation. Expression of the EPO receptor is not restricted to hematopoietic cells and exhibits a multi-tissue distribution that includes neural cells, vascular endothelium and muscle progenitor cells. The ability for EPO to stimulate progenitor cell proliferation and prevent apoptosis is critical for maintenance of the erythroid lineage, but is also observed in neural and muscle progenitor cells. Mice lacking the EPO receptor die in utero due to severe anemia. However, even prior to lack of erythroid cell production in the embryo proper, these mice exhibit increased apoptosis in the brain as early as E10.5 and a reduction in the number of neural progenitor cells. Corresponding cultures of primary neural cells exhibit decreased neuron generation and increased sensitivity to reduced oxygen tension, and neurons do not survive after 24 h at low oxygen tension. In contrast, hypoxia induces EPO and EPO receptor in wild-type neuronal cells, and EPO enhances neuron survival at low oxygen tension. In vivo EPO is neuroprotective in adult animal models for brain ischemia. Induction of EPO and its receptor by hypoxia likely contributes to its neuroprotective activity and selective cell survival in the brain during hypoxic stress.


  

Author Contacts

Constance Tom Noguchi, PhD
Molecular Medicine Branch, NIDDK, National Institutes of Health
Building 10, Room 9N307, 10 Center DR MSC-1822
Bethesda, MD 20892-1822 (USA)
Tel. +1 301 496 1163, Fax +1 301 402 0101, E-Mail cnoguchi@helix.nih.gov

  

Article Information

Number of Print Pages : 8
Number of Figures : 4, Number of Tables : 0, Number of References : 21

  

Publication Details

Neurodegenerative Diseases

Vol. 3, No. 1-2, Year 2006 (Cover Date: May 2006)

Journal Editor: Nitsch, R.M. (Zürich)
ISSN: 1660–2854 (print), 1660–2862 (Online)

For additional information: http://www.karger.com/NDD


Article / Publication Details

First-Page Preview
Abstract of Signaling and Stem Cells

Published online: 5/17/2006

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 0

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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