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Vol. 3, No. 1-2, 2006
Issue release date: May 2006
Section title: Signaling and Stem Cells
Neurodegenerative Dis 2006;3:94–100
(DOI:10.1159/000092099)

Induction of Signalling in Non-Erythroid Cells by Pharmacological Levels of Erythropoietin

Dunlop E.A. · Percy M.J. · Boland M.P. · Maxwell A.P. · Lappin T.R.
aCentre for Cancer Research and Cell Biology, Queen’s University Belfast, bHaematology Department, and cNephrology Research Group, Belfast City Hospital, Belfast, UK

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Article / Publication Details

First-Page Preview
Abstract of Signaling and Stem Cells

Published online: 5/17/2006

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 0

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD

Abstract

Erythropoiesis is maintained by the hormone erythropoietin (Epo) binding to its cognate receptor (EpoR) on erythroid progenitor cells. The Epo-EpoR interaction initiates a signal transduction process that regulates the survival, growth and differentiation of these cells. Originally perceived as highly lineage-restricted, Epo is now recognised to have pleiotropic effects extending beyond the maintenance of red cell mass. Functional interactions between Epo and EpoR have been demonstrated in numerous cells and tissues. EpoR expression on neoplastic cells leads to concern that recombinant human erythropoietin, used to treat anaemia in cancer patients, may augment tumour growth. Here we demonstrate that EPO, at pharmacological concentrations, can activate three major signalling cascades, viz. the Jak2/STAT5, Ras/ERK and PI3K/Akt pathways in non-small cell lung carcinoma (NSCLC) cell lines. EpoR synthesis is normally under the control of GATA-1, but NSCLC cells exhibit decreased GATA-1 levels compared to GATA-2, -3 and -6, suggesting that GATA-1 is not essential for EpoR production. The increased Epo-induced signalling was not associated with a growth advantage for the NSCLC cells.


  

Author Contacts

Prof. T.R. Lappin
Department of Haematology, Centre for Cancer Research and Cell Biology
Queen’s University Belfast, U Floor, Tower Block, Belfast City Hospital
Lisburn Road, Belfast, BT9 7AB (UK)
Tel. +44 2890 263718, Fax +44 2890 263927, E-Mail t.lappin@qub.ac.uk

  

Article Information

Number of Print Pages : 7
Number of Figures : 4, Number of Tables : 0, Number of References : 29

  

Publication Details

Neurodegenerative Diseases

Vol. 3, No. 1-2, Year 2006 (Cover Date: May 2006)

Journal Editor: Nitsch, R.M. (Zürich)
ISSN: 1660–2854 (print), 1660–2862 (Online)

For additional information: http://www.karger.com/NDD


Article / Publication Details

First-Page Preview
Abstract of Signaling and Stem Cells

Published online: 5/17/2006

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 0

ISSN: 1660-2854 (Print)
eISSN: 1660-2862 (Online)

For additional information: http://www.karger.com/NDD


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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