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Vol. 1, No. 2, 2006
Issue release date: April 2006
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Breast Care 2006;1:113-116
(DOI:10.1159/000092110)
Review Article · Übersichtsarbeit

Tumor Cell Dissemination and Metastasis in Breast Cancer: Selected Presentations at the 28th San Antonio Breast Cancer Symposium 2005

Müller V.a* · Stickeler E.b*
aUniversitätsklinikum Hamburg-Eppendorf, bUniversitätsfrauenklinik Freiburg, Germany Breast Care 2006;1:113-116 (DOI:10.1159/000092110)

Abstract

Distant metastases are the leading cause of breast cancer- related deaths. Early tumor cell dissemination as the first step in the metastatic cascade can be detected in breast cancer patients using sensitive assays. Clinical studies demonstrated that the presence of disseminated tumor cells in bone marrow identified with immunocytochemical assays at primary diagnosis is a strong prognostic factor indicating a biologic relevance of these cells. However, the molecular basis enabling malignant cells to grow out as manifest metastasis are still not fully understood. In this context, considerable progress has been made by analyzing distinct gene function in the metastatic cascade as well as in establishing gene expression signatures which are able to classify the risk of developing organ-specific metastases. Here, we briefly describe and discuss new aspects of these topics presented at the 28th San Antonio Breast Cancer Symposium 2005.

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