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Vol. 55, No. 2, 2006
Issue release date: May 2006
Section title: Original Paper
Eur Neurol 2006;55:74–79
(DOI:10.1159/000092306)

Epilepsy and Obstructive Sleep Apnea

Höllinger P. · Khatami R. · Gugger M. · Hess C.W. · Bassetti C.L.
aDepartments of Neurology and Pneumology, University Hospital Bern, Bern, and bDepartment of Neurology, University Hospital Zürich, Zürich, Switzerland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/23/2005
Accepted: 1/4/2006
Published online: 3/10/2006

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE

Abstract

A few publications documented the coexistence of epilepsy and obstructive sleep apnea (OSA). The extent, nature, and clinical relevance of this association remain poorly understood. We retrospectively reviewed the database of our sleep center to identify patients with both sleep apnea and epilepsy. Characteristics of epilepsy, sleep history, presence of excessive daytime sleepiness [Epworth Sleepiness Scale (ESS)] and polysomnographic data were assessed. The effect of continuous positive airway pressure (CPAP) on seizure reduction was prospectively analyzed after a median interval of 26 months (range: 2–116 months) from the diagnosis of OSA. OSA was found in 29 epilepsy patients (25 men and 4 women) with a median age of 56 years (range: 37–79). The median apnea hypopnea index was 33 (range: 10–85), the oxygen desaturation index was 12 (range 0–92), and 52% of the patients had an ESS score >10. In 27 patients, epilepsy appeared 1 month to 44 years prior to the diagnosis of OSA. In 21 patients, the appearance of OSA symptoms coincided with a clear increase in seizure frequency or the first appearance of a status epilepticus. Treatment with CPAP was continued with good compliance in 12 patients and led to a significant reduction of both ESS scores and seizure frequency in 4 patients. Our data suggest the importance of considering diagnosis and treatment of OSA in epilepsy patients with poor seizure control and/or reappearance of seizures after a seizure-free interval.


  

Author Contacts

Prof. Dr. Claudio L. Bassetti
Neurologische Poliklinik, Universitätsspital
Frauenklinikstrasse 26
CH–8091 Zürich (Switzerland)
Tel. +41 44 255 5503, Fax +41 44 255 4649, E-Mail claudio.bassetti@usz.ch

  

Article Information

Received: September 23, 2005
Accepted: January 4, 2006
Published online: March 24, 2006
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 2, Number of References : 22

  

Publication Details

European Neurology

Vol. 55, No. 2, Year 2006 (Cover Date: May 2006)

Journal Editor: Bogousslavsky, J. (Lausanne)
ISSN: 0014–3022 (print), 1421–9913 (Online)

For additional information: http://www.karger.com/ENE


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/23/2005
Accepted: 1/4/2006
Published online: 3/10/2006

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: http://www.karger.com/ENE


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