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Vol. 27, No. 2, 2006
Issue release date: April 2006
Section title: Mini Review
Tumor Biol 2006;27:59–70
(DOI:10.1159/000092323)

Cancer Stem Cells and Differentiation Therapy

Sell S.
Wadsworth Center and Ordway Research Institute, Albany, N.Y., USA

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Article / Publication Details

First-Page Preview
Abstract of Mini Review

Received: 11/8/2005
Accepted: 11/8/2005
Published online: 4/24/2006

Number of Print Pages: 12
Number of Figures: 3
Number of Tables: 1

ISSN: 1010-4283 (Print)
eISSN: 1423-0380 (Online)

For additional information: http://www.karger.com/TBI

Abstract

Cancers arise from stem cells in adult tissues and the cells that make up a cancer reflect the same stem cell → progeny → differentiation progression observed in normal tissues. All adult tissues are made up of lineages of cells consisting of tissue stem cells and their progeny (transit-amplifying cells and terminally differentiated cells); the number of new cells produced in normal tissue lineages roughly equals the number of old cells that die. Cancers result from maturation arrest of this process, resulting in continued proliferation of cells and a failure to differentiate and die. The biological behavior, morphological appearance, and clinical course of a cancer depend on the stage of maturation at which the genetic lesion is activated. This review makes a comparison of cancer cells to embryonic stem cells and to adult tis sue stem cells while addressing two basic questions: (1) Where do cancers come from?, and (2) How do cancers grow? The answers to these questions are critical to the development of approaches to the detection, prevention, and treatment of cancer.


  

Author Contacts

Stewart Sell, MD
New York State Health Department, Wadsworth Center
PO Box 509, Room C-551, Empire State Plaza
Albany, NY 12201 (USA)
Tel. +1 518 474 0547, Fax +1 518 473 2900/518 402 5381, E-Mail ssell@wadsworth.org

  

Article Information

Received: November 8, 2005
Accepted: November 8, 2005
Published online: March 24, 2006
Number of Print Pages : 12
Number of Figures : 3, Number of Tables : 1, Number of References : 129

  

Publication Details

Tumor Biology (Tumor Markers, Tumor Targeting and Translational Cancer Research)

Vol. 27, No. 2, Year 2006 (Cover Date: April 2006)

Journal Editor: Stigbrand, T. (Umeå)
ISSN: 1010–4283 (print), 1423–0380 (Online)

For additional information: http://www.karger.com/TBI


Article / Publication Details

First-Page Preview
Abstract of Mini Review

Received: 11/8/2005
Accepted: 11/8/2005
Published online: 4/24/2006

Number of Print Pages: 12
Number of Figures: 3
Number of Tables: 1

ISSN: 1010-4283 (Print)
eISSN: 1423-0380 (Online)

For additional information: http://www.karger.com/TBI


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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