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Serine Proteases Affecting Blood Coagulation and Fibrinolysis from Snake Venoms

Kini R.M.

Author affiliations

Department of Biological Sciences, Faculty of Science, National University of Singapore, Singapore; Department of Biochemistry, VCU Medical Center, Virginia Commonwealth University, Richmond, Va., USA

Corresponding Author

R. Manjunatha Kini

Protein Science Laboratory, Department of Biological Sciences

Faculty of Science, 14 Science Drive 4

National University of Singapore, Singapore 117543 (Singapore)

Tel. +65 6874 5235, Fax +65 6779 2486, E-Mail dbskinim@nus.edu.sg

Related Articles for ""

Pathophysiol Haemos Thromb 2005;34:200–204

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Snake venom proteases, in addition to their contribution to the digestion of the prey, affect various physiological functions. They affect platelet aggregation, blood coagulation, fibrinolysis, complement system, blood pressure and nervous system. This review provides a ready reference for serine proteases that interfere in blood coagulation and fibrinolysis. They exhibit their activity by activation of specific zymogens of coagulation factors. These serine proteases serve as tools to study molecular details in the activation of specific factors involved in coagulation and fibrinolytic cascades and are useful in treating various thrombotic and hemostatic conditions.

© 2005 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: May 19, 2006
Issue release date: May 2006

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)

For additional information: http://www.karger.com/PHT

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