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Cover

Genome and Disease

Editor(s): Volff J.-N. (Würzburg) 
Table of Contents
Vol. 1, No. , 2006
Section title: Paper
Volff J-N (ed): Genome and Disease. Genome Dyn. Basel, Karger, 2006, vol 1, pp 84–103
(DOI:10.1159/000092502)

Telomeres and Telomerase in Stem Cells during Aging and Disease

Ju Z. · Rudolph K.L.
Department of Gastroenterology, Hepatology & Endocrinology, Medical School Hannover, Hannover, Germany

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: March 28, 2006
Cover Date: 2006

Number of Print Pages: 20
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8029-8 (Print)
eISBN: 978-3-318-01290-3 (Online)

Abstract

Cell cycle checkpoints induced by telomere dysfunction represent one of the major in vivo tumor suppressor mechanisms preventing cancer but at the same time provoking age dependent decline in self-renewal and regeneration of tissues and organs. On the other hand, telomere shortening contributes to the initiation of cancer by inducing chromosomal instability. Telomere function and telomerase activity are mainly associated with actively proliferating cells. Since stem cells are continuously proliferating throughout lifetime, it is of great interest to explore the role of telomeres and telomerase in stem cells. Although most stem cell compartments express telomerase, the level of telomerase activity is not sufficient to maintain telomere length of stem cells during aging. Stem cells appear to have tighter DNAdamage checkpoint control in comparison to somatic cells, which may reflect the need to protect this long lasting cell compartment against malignant transformation. These enhanced checkpoint responses may have a detrimental impact on stem cell function, by causing increased sensitivity towards senescence or apoptosis induced by telomere shortening. This review summarizes our knowledge on telomere dynamics and its functional impact on stem cells during aging and transformation.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: March 28, 2006
Cover Date: 2006

Number of Print Pages: 20
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8029-8 (Print)
eISBN: 978-3-318-01290-3 (Online)


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.