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Vol. 65, No. 6, 2006
Issue release date: June 2006
Section title: Original Paper
Horm Res 2006;65:269–275
(DOI:10.1159/000092536)

Increased Aortic Intima-Media Thickness Is Related to Lipid Profile in Newborns with Intrauterine Growth Restriction

Koklu E. · Kurtoglu S. · Akcakus M. · Koklu S. · Buyukkayhan D. · Gumus H. · Yikilmaz A.
Department of Neonatology and Paediatric Endocrinology and Metabolism, Erciyes University, School of Medicine, Kayseri, Turkey

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/15/2005
Accepted: 2/24/2006
Published online: 6/9/2006
Issue release date: June 2006

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 3

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP

Abstract

Background and Aim: Low birth-weight is known to be associated with an increase in cardiovascular risk similar to that seen with major environmental risk factors, such as cigarette smoking or hypertension. Much epidemiological evidence has linked low birth-weight with hypertriglyceridaemia. Method: We measured aortic wall thickness by ultrasonography and lipid profile in 40 newborn babies with intrauterine growth restriction and 40 controls. Results: Maximum and mean aortic intima-media thickness were significantly higher in the babies with intrauterine growth retardation (0.58 ± 0.06, 0.52 ± 0.03 mm, respectively) than in controls (0.44 ± 0.05, 0.40 ± 0.03 mm, p < 0.0001, p < 0.0001, respectively), more so after adjustment for birth-weight (maximum intima-media thickness: 0.23 ± 0.03 mm/kg vs. 0.12 ± 0.02 mm/kg, p < 0.0001; mean intima-media thickness: 0.21 ± 0.02 mm/kg vs. 0.11 ± 0.01 mm/kg, p < 0·0001). Serum triglyceride levels were significantly higher in the intrauterine growth retardation group (48.9 ± 14.8 mg/dl) compared with the control group (32.5 ± 9.8 mg/dl, p < 0.0001). The mean body mass index, prepregnancy weight, weight gain during pregnancy, maternal LDL cholesterol level and, height of the mothers were significantly lower in the intrauterine growth retardation group compared with the control group. For maximum aIMT, significant associations included the ponderal index (p = <0.01), length (p = 0.01) and serum triglyceride levels of infants (p = 0.02). Conclusion: Newborn babies with growth restriction have significant maximum aortic thickening with hypertriglyceridaemia, suggesting that prenatal events might predispose to later cardiovascular risk.


  

Author Contacts

Selim Kurtoglu, MD
Department of Paediatrics, Division of Neonatology and
Paediatric Endocrinology and Metabolism, Erciyes University, School of Medicine
TR–38039 Kayseri (Turkey)
Tel. +90 352 438 0076, Fax +90 352 437 5825, E-Mail selimk@erciyes.edu.tr

  

Article Information

Received: September 15, 2005
Accepted: February 24, 2006
Published online: April 5, 2006
Number of Print Pages : 7
Number of Figures : 2, Number of Tables : 3, Number of References : 23

  

Publication Details

Hormone Research (From Developmental Endocrinology to Clinical Research)

Vol. 65, No. 6, Year 2006 (Cover Date: June 2006)

Journal Editor: Czernichow, P. (Paris)
ISSN: 0301–0163 (print), 1423–0046 (Online)

For additional information: http://www.karger.com/HRE


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/15/2005
Accepted: 2/24/2006
Published online: 6/9/2006
Issue release date: June 2006

Number of Print Pages: 7
Number of Figures: 2
Number of Tables: 3

ISSN: 1663-2818 (Print)
eISSN: 1663-2826 (Online)

For additional information: http://www.karger.com/HRP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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