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Vol. 74, No. 4, 2007
Issue release date: July 2007
Section title: Clinical Investigations
Respiration 2007;74:387–393
(DOI:10.1159/000092547)

Evaluating the Use of a Streptococcus pneumoniae Urinary Antigen Detection Kit for the Management of Community-Acquired Pneumonia in Japan

Kobashi Y. · Yoshida K. · Miyashita N. · Niki Y. · Matsushima T.
Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan

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Article / Publication Details

First-Page Preview
Abstract of Clinical Investigations

Received: 8/15/2005
Accepted: 12/19/2005
Published online: 3/31/2006

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 4

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES

Abstract

Background: The urinary antigen detection kit for Streptococcus pneumoniae was tested. Objectives: It was our aim to evaluate the usefulness of the immunochromatographic membrane test by doing a large prospective study of community-acquired pneumonia (CAP) in Japan. Methods: We prospectively evaluated the use of the S. pneumoniae urinary antigen detection kit and analyzed the treatment and clinical effect seen in patients with positive test kit results. One hundred and fifty-six patients with CAP admitted to our hospital between October 2001 and September 2003 were evaluated. Results: In 49% of these CAP patients, the causative microorganisms were isolated. S. pneumoniae was suspected to be the causative microorganism in 15%, but positive results of the urinary antigen detection kit indicated S. pneumoniae to be a probable microorganism in 28%, even though antibiotics had previously been administered to half of the patients. The kit was particularly useful for diagnosing patients with poor quality sputum in whom antibiotics treatment nevertheless had to be selected. Antibiotics appropriate for S. pneumoniae (mainly penicillin) were given. The treatment was found to have excellent clinical results in 89% of the CAP patients. Conclusions: The S. pneumoniae urinary antigen detection kit was considered to be useful in selecting treatment since there was a high level of clinical effectiveness when the most suitable antibiotics were immediately administered to positive patients. The use of the S. pneumoniae urinary antigen kit is rapid and simple compared with conventional microbiological procedures.


  

Author Contacts

Yoshihiro Kobashi MD
Division of Respiratory Diseases, Department of Medicine
Kawasaki Medical School, 577 Matsushima
Kurashiki 701-0192 (Japan)
Tel. +81 86 462 1111, Fax +81 86 464 1041, E-Mail yoshihiro@med.kawasaki-m.ac.jp

  

Article Information

Received: August 15, 2005
Accepted after revision: December 19, 2005
Published online: March 31, 2006
Number of Print Pages : 7
Number of Figures : 0, Number of Tables : 4, Number of References : 27

  

Publication Details

Respiration (International Journal of Thoracic Medicine)

Vol. 74, No. 4, Year 2007 (Cover Date: July 2007)

Journal Editor: Bolliger, C.T. (Cape Town)
ISSN: 0025–7931 (print), 1423–0356 (Online)

For additional information: http://www.karger.com/RES


Article / Publication Details

First-Page Preview
Abstract of Clinical Investigations

Received: 8/15/2005
Accepted: 12/19/2005
Published online: 3/31/2006

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 4

ISSN: 0025-7931 (Print)
eISSN: 1423-0356 (Online)

For additional information: http://www.karger.com/RES


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