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Table of Contents
Vol. 27, No. 3, 2006
Issue release date: May 2006
Section title: Research Article
Tumor Biol 2006;27:133–141
(DOI:10.1159/000092774)

Matrix Metalloproteinases 21 and 26 Are Differentially Expressed in Esophageal Squamous Cell Cancer

Ahokas K.a · Karjalainen-Lindsberg M.-L.b · Sihvo E.c · Isaka K.d · Salo J.c · Saarialho-Kere U.a, e
Departments of aDermatology, bPathology, and cCardiothoracic Surgery, Helsinki University Central Hospital, and Biomedicum Helsinki, University of Helsinki, Helsinki, Finland; dDepartment of Obstetrics and Gynecology, Tokyo Medical University, Tokyo, Japan; eDepartment of Dermatology, Karolinska Institute, Stockholm Söder Hospital, Stockholm, Sweden

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Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: June 26, 2005
Accepted: October 24, 2005
Published online: May 08, 2006
Issue release date: May 2006

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 1

ISSN: 1010-4283 (Print)
eISSN: 1423-0380 (Online)

For additional information: http://www.karger.com/TBI

Abstract

Matrix metalloproteinase 21 (MMP-21) and MMP-26 (matrilysin-2) are the two newest members of the human MMP gene family that have both been suggested to play an important role in epithelial tumor progression and to be regulated via the Wnt signaling pathway. We studied their expression in 34 esophageal squamous cell carcinomas and non-neoplastic epithelium. MMP-21 protein was detected in cancer cells and inflammatory cells at the invasive front. Its expression was associated with invasion, inflammation, apoptotic and well-differentiated areas of the tumors, but not with cell proliferation. Unlike MMP-21, MMP-26 protein was already upregulated in incipient invasion and its expression associated with regions of low differentiation being more sporadic at the invasive front. MMP-21 was detected basally in KYSE-30 and OE21 esophageal squamous cell carcinoma cells, while MMP-26 was absent. None of the several cytokines and matrices tested were capable of consistently upregulating MMP-21 or MMP-26 mRNA expression in these two cell lines. Our results suggest that during esophageal tumorigenesis, MMP-21 and MMP-26 have different, unique expression patterns both being tightly regulated and induced in the vicinity of inflammation. MMP-21 may provide a marker for differentiating tumor areas. The putative role of MMP-26 as a marker of dysplasia and incipient invasion warrants further studies.

© 2006 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: June 26, 2005
Accepted: October 24, 2005
Published online: May 08, 2006
Issue release date: May 2006

Number of Print Pages: 9
Number of Figures: 3
Number of Tables: 1

ISSN: 1010-4283 (Print)
eISSN: 1423-0380 (Online)

For additional information: http://www.karger.com/TBI


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