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Table of Contents
Vol. 77, No. 1, 2006
Issue release date: July 2006
Section title: Original Paper
Urol Int 2006;77:69–75
(DOI:10.1159/000092937)

Evaluation of Fluorodeoxyglucose Positron Emission Tomography Imaging in Metastatic Transitional Cell Carcinoma with and without Prior Chemotherapy

Liu I.J.a · Lai Y.-H.a · Espiritu J.I.b · Segall G.M.b · Srinivas S.c · Nino-Murcia M.d · Terris M.K.a, e
Sections of aUrology, bNuclear Medicine, cRadiology and dOncology, Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif., and eSections of Urology, Augusta Veterans Affairs Medical Center and Medical College of Georgia, Augusta, Ga., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 17, 2004
Accepted: February 20, 2006
Published online: May 12, 2009
Issue release date: July 2006

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 0

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN

Abstract

Introduction: This study was designed to determine the value of fluorodeoxyglucose (FDG) positron emission tomography (PET) in the evaluation of metastatic transitional cell carcinoma (TCC). Methods: Fifty-eight FDG PET scans were performed on 46 consecutive patients with TCC. Results were correlated with radiologic, pathologic, and histologic findings in these patients and the sensitivity of PET for detecting malignancy in untreated TCC patients (n = 48) was compared to the sensitivity in patients who had undergone prior chemotherapy (n = 10). Results: Of 48 scans in patients who had no prior systemic chemotherapy, 10 had increased uptake in proven metastatic TCC lesions and 3 PET studies failed to reveal metastatic TCC (sensitivity 76.9%). In patients free of metastatic disease, 33 revealed no abnormal uptake and 1 study revealed a suspicious area in a patient free of metastases (specificity = 97.1%). However, in 10 patients imaged after receiving chemotherapy, the sensitivity fell to 50% for the detection of histologically confirmed residual/recurrent tumor by PET. Conclusions: FDG PET detects increased metabolic activity. After chemotherapy, viable cancer cells may still be present but with a diminished metabolic rate. As a result, PET imaging is often useful in the evaluation of untreated metastatic TCC metastasis but should be interpreted with caution in patients who have received prior chemotherapy.

© 2006 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 17, 2004
Accepted: February 20, 2006
Published online: May 12, 2009
Issue release date: July 2006

Number of Print Pages: 7
Number of Figures: 4
Number of Tables: 0

ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)

For additional information: http://www.karger.com/UIN


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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