Journal Mobile Options
Table of Contents
Vol. 27, No. 4, 2006
Issue release date: May 2006
Section title: Research Article
Tumor Biol 2006;27:187–194
(DOI:10.1159/000093022)

Elevated Serum Soluble CD30 Precedes the Development of AIDS-Associated Non-Hodgkin’s B Cell Lymphoma

Breen E.C. · Fatahi S. · Epeldegui M. · Boscardin W.J. · Detels R. · Martínez-Maza O.
Departments of aObstetrics and Gynecology and bMicrobiology, Immunology, and Molecular Genetics, David Geffen School of Medicine and Departments of cBiostatistics and dEpidemiology, School of Public Health, University of California, Los Angeles, Calif., USA

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Automatic perpetual access to all articles of the subscribed year(s)
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: 7/30/2005
Accepted: 10/24/2005
Published online: 5/22/2006

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 1

ISSN: 1010-4283 (Print)
eISSN: 1423-0380 (Online)

For additional information: http://www.karger.com/TBI

Abstract

CD30, first described as the Ki antigen on malignant B cells in Hodgkin’s lymphoma, is also expressed on normal activated B and T cells. It can be cleaved from the cell surface and detected in normal serum as soluble CD30 (sCD30), where it can be an indicator of levels of immune activation. In a cross-sectional study utilizing archived sera at a time point close to but preceding a diagnosis of acquired immunodeficiency syndrome (AIDS)-associated non-Hodgkin’s B cell lymphoma, AIDS lymphoma subjects (n = 49) showed elevated mean levels of sCD30 compared to controls with AIDS but no malignancy (n = 44, p < 0.01), HIV-infected but relatively healthy (n = 47, p < 0.001), or HIV-seronegative controls (n = 44, p < 0.001). Serum sCD30 was significantly correlated to serum levels of the B cell cytokines interleukin-6 (IL-6), IL-10, and sCD23, but only among lymphoma subjects (p ≤ 0.05). Correlations between sCD30 and other markers of immune system activation were seen among all HIV-infected subjects (sCD27, sCD44, CXCL13, p < 0.05). These observations suggest that sCD30, especially in combination with other immune system molecules, could be an important biomarker for an immune system environment conducive to B cell hyperactivation and the development of AIDS-associated B cell lymphoma.


  

Author Contacts

Elizabeth Crabb Breen
David Geffen School of Medicine at UCLA
Box 951740
Los Angeles, CA 90095-1740 (USA)
Tel. +1 310 206 6846, Fax +1 310 206 5387, E-Mail ebreen@mednet.ucla.edu

  

Article Information

Received: July 30, 2005
Accepted after revision: October 24, 2005
Published online: April 27, 2006
Number of Print Pages : 8
Number of Figures : 3, Number of Tables : 1, Number of References : 25

  

Publication Details

Tumor Biology (Tumor Markers, Tumor Targeting and Translational Cancer Research)

Vol. 27, No. 4, Year 2006 (Cover Date: May 2006)

Journal Editor: Stigbrand, T. (Umeå)
ISSN: 1010–4283 (print), 1423–0380 (Online)

For additional information: http://www.karger.com/TBI


Article / Publication Details

First-Page Preview
Abstract of Research Article

Received: 7/30/2005
Accepted: 10/24/2005
Published online: 5/22/2006

Number of Print Pages: 8
Number of Figures: 3
Number of Tables: 1

ISSN: 1010-4283 (Print)
eISSN: 1423-0380 (Online)

For additional information: http://www.karger.com/TBI


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.