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Vol. 22, No. 1, 2006
Issue release date: June 2006
Section title: Original Research Article
Dement Geriatr Cogn Disord 2006;22:27–34
(DOI:10.1159/000093101)

Progression to Dementia in Clinical Subtypes of Mild Cognitive Impairment

Alexopoulos P. · Grimmer T. · Perneczky R. · Domes G. · Kurz A.
aDepartment of Psychiatry and Psychotherapy, Technische Universität, München, and bDepartment of Psychiatry and Psychotherapy, Universität Rostock, Rostock, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 1/16/2006
Published online: 6/19/2006

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

Abstract

Objective: To examine the outcome among patients diagnosed with different types of mild cognitive impairment (MCI). Patients: A follow-up examination (average follow-up period: 3.49 ± 2.2 years) was performed in 81 cognitively impaired, non-demented patients aged >55 years at baseline. Results: 8 of 32 patients with amnestic MCI (25%), 22 of 41 patients with multiple-domain MCI (54%), and 3 of 8 patients with single non-memory MCI (37.5%) progressed to dementia. The clinical type of MCI is significantly associated with the likelihood of conversion to dementia. Discussion: When the clinical syndrome of MCI evolves on a neurodegenerative basis, the multiple-domain type of MCI has a less favorable prognosis than the amnestic type and may represent a more advanced prodromal stage of dementia.


  

Author Contacts

Dr. med. Panos Alexopoulos
Klinik und Poliklinik für Psychiatrie und Psychotherapie, Universität Rostock
Gehlsheimer Strasse 20
DE–18147 Rostock (Germany)
Tel. +49 381 494 9501, Fax +49 381 494 9502, E-Mail palexopoulos@freemail.gr

  

Article Information

Accepted: January 16, 2006
Published online: May 4, 2006
Number of Print Pages : 8
Number of Figures : 0, Number of Tables : 4, Number of References : 46

  

Publication Details

Dementia and Geriatric Cognitive Disorders

Vol. 22, No. 1, Year 2006 (Cover Date: June 2006)

Journal Editor: Chan-Palay, V. (New York, N.Y.)
ISSN: 1420–8008 (print), 1421–9824 (Online)

For additional information: http://www.karger.com/DEM


Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: 1/16/2006
Published online: 6/19/2006

Number of Print Pages: 8
Number of Figures: 0
Number of Tables: 4

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM


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