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Vol. 19, No. 4, 2006
Issue release date: July 2006
Section title: Original Paper
Skin Pharmacol Appl Skin Physiol 2006;19:216–223
(DOI:10.1159/000093117)

Follicular Penetration: Development of a Method to Block the Follicles Selectively against the Penetration of Topically Applied Substances

Teichmann A. · Otberg N. · Jacobi U. · Sterry W. · Lademann J.
Center for Experimental and Applied Cutaneous Physiology, Department of Dermatology, Medical Faculty Charité, Berlin, Germany

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/23/2005
Accepted: 9/6/2005
Published online: 7/14/2006
Issue release date: July 2006

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

Investigations into the penetration pathways of topically applied substances through the skin play an important role in dermatological science. Recently, the hair follicles have increasingly been recognized as an important pathway for percutaneous penetration, although the role of the follicles has still not been clarified in detail. Therefore, the aim of the present study was to develop an in vivo method for the analysis of the follicular rate of penetration processes. In order to reach this goal, the follicles were excluded from the penetration process of topically applied substances. Different study designs were evaluated, and we were able to show that the application of nail varnish to each follicular orifice represents an effective method of blocking the follicles selectively against the penetration of topically applied substances. In dermatological science, there is new information on the physiology of skin penetration processes, thus allowing examination of the follicular rate of penetration and improvement of the pharmacokinetics of topically applied substances.

© 2006 S. Karger AG, Basel


  

Author Contacts

Alexa Teichmann, MD
Center for Experimental and Applied Cutaneous Physiology
Department of Dermatology, Medical Faculty Charité, Schumannstrasse 20/21
DE–10117 Berlin (Germany)
Tel. +49 30 450 518 106, Fax +49 30 450 518 918, E-Mail alexa.teichmann@charite.de

  

Article Information

Received: May 23, 2005
Accepted after revision: September 6, 2005
Published online: May 4, 2006
Number of Print Pages : 8
Number of Figures : 5, Number of Tables : 0, Number of References : 38

  

Publication Details

Skin Pharmacology and Physiology (Journal of Pharmacological and Biophysical Research)

Vol. 19, No. 4, Year 2006 (Cover Date: July 2006)

Journal Editor: Lademann, J. (Berlin)
ISSN: 1660–5527 (print), 1660–5535 (Online)

For additional information: http://www.karger.com/SPP


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/23/2005
Accepted: 9/6/2005
Published online: 7/14/2006
Issue release date: July 2006

Number of Print Pages: 8
Number of Figures: 5
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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