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Vol. 22, No. 2-3, 2006
Issue release date: July 2006
Section title: Original Paper
Cerebrovasc Dis 2006;22:155–161
(DOI:10.1159/000093245)

Lobar Brain Hemorrhages and White Matter Changes: Clinical, Radiological and Laboratorial Profiles

Maia L.F.a · Vasconcelos C.b · Seixas S.c · Magalhães R.d · Correia M.a
Departments of aNeurology and bNeuroradiology, Hospital Geral Santo António, cInstituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP) and dPopulation Study Department, ICBAS, UP, Porto, Portugal

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/14/2005
Accepted: 2/9/2006
Published online: 7/14/2006
Issue release date: July 2006

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED

Abstract

Background: White matter changes have several histopathologic correlates including cerebral amyloid angiopathy (CAA). The aim of this study was to characterize the clinical, laboratorial and neuroradiological profile of a CAA-related lobar hemorrhages case series. Methods: A cohort of 50 consecutive patients with cerebral lobar hemorrhages was studied and clinical, radiological data and ApoE polymorphisms were analyzed. White matter changes were graded and microbleeds were characterized according to number and location using T2* MRI. Results: A statistically significant association was found between the prestroke cognitive performance and poststroke dementia and between hemorrhage volume and mortality. More severe white matter changes were found in probable CAA when comparing to possible CAA. The most prominent white matter lesions are associated with the presence and the number of microbleeds. The frequency of APOE υ2 and υ4 alleles was higher in this cohort when compared to a Northern Portuguese population. Conclusion: White matter changes are frequent in lobar hemorrhage patients and are associated with cortical microbleeds, the radiological hallmark of CAA. Therefore, white matter changes may be the sole phenotype of CAA and, potentially, involved in the pre-stroke cognitive impairment presented by the patients, which are genetically distinct from the population in general.

© 2006 S. Karger AG, Basel


  

Publication Details

Cerebrovascular Diseases

Vol. 22, No. 2-3, Year 2006 (Cover Date: July 2006)

Journal Editor: Bogousslavsky, J. (Lausanne)
ISSN: 1015–9770 (print), 1421–9786 (Online)

For additional information: http://www.karger.com/CED


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 6/14/2005
Accepted: 2/9/2006
Published online: 7/14/2006
Issue release date: July 2006

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: http://www.karger.com/CED


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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